Detailed information of TA system TA225261

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2063342..2063564
• Replicon: chromosome
• Accession: NZ_CP087290
• Organism: Escherichia coli strain APEC 102026

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: LO741_RS09985
• Protein ID: WP_001295224.1
• Coordinates: 2063342..2063449 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2063498..2063564 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO741_RS09965	2059337..2060908	+	1572	WP_001204944.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LO741_RS09970	2060905..2061096	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LO741_RS09975	2061093..2062772	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
LO741_RS09980	2062859..2062966	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO741_RS09985	2063342..2063449	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	2063498..2063564	+	67	-	-	Antitoxin
LO741_RS09990	2063825..2063932	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO741_RS09995	2064308..2064415	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
LO741_RS10000	2064891..2066162	+	1272	WP_001318103.1	aromatic amino acid transport family protein	-
LO741_RS10005	2066192..2067196	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LO741_RS10010	2067193..2068176	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2058205..2059185	980

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T225261 WP_001295224.1 NZ_CP087290:c2063449-2063342 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T225261 NZ_CP121087:3827115-3827429 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAATCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT225261 NZ_CP087290:2063498-2063564 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin