Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 2062859..2063081 Replicon chromosome
Accession NZ_CP087290
Organism Escherichia coli strain APEC 102026

Toxin (Protein)


Gene name ldrD Uniprot ID S1NWX0
Locus tag LO741_RS09980 Protein ID WP_001295224.1
Coordinates 2062859..2062966 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 2063023..2063081 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO741_RS09960 2058205..2059185 - 981 WP_000019440.1 IS5-like element ISKpn26 family transposase -
LO741_RS09965 2059337..2060908 + 1572 WP_001204944.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
LO741_RS09970 2060905..2061096 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
LO741_RS09975 2061093..2062772 + 1680 WP_001562264.1 cellulose biosynthesis protein BcsG -
LO741_RS09980 2062859..2062966 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2063023..2063081 + 59 - - Antitoxin
LO741_RS09985 2063342..2063449 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
LO741_RS09990 2063825..2063932 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
LO741_RS09995 2064308..2064415 - 108 WP_000170738.1 type I toxin-antitoxin system toxin Ldr family protein -
LO741_RS10000 2064891..2066162 + 1272 WP_001318103.1 aromatic amino acid transport family protein -
LO741_RS10005 2066192..2067196 - 1005 WP_000107036.1 dipeptide ABC transporter ATP-binding subunit DppF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2058205..2059185 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3882.70 Da        Isoelectric Point: 9.0157

>T225259 WP_001295224.1 NZ_CP087290:c2062966-2062859 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T225259 NZ_CP121087:3299547-3299732 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 59 bp

>AT225259 NZ_CP087290:2063023-2063081 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TSJ7

Antitoxin

Download structure file

References