Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2293263..2293825 Replicon chromosome
Accession NZ_CP087287
Organism Escherichia coli strain APEC 16-1068

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag LO742_RS11415 Protein ID WP_000605675.1
Coordinates 2293547..2293825 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag LO742_RS11410 Protein ID WP_000781370.1
Coordinates 2293263..2293547 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO742_RS11395 (2288444) 2288444..2291491 + 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -
LO742_RS11400 (2291504) 2291504..2292388 + 885 WP_001240584.1 formate dehydrogenase N subunit beta -
LO742_RS11405 (2292381) 2292381..2293034 + 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
LO742_RS11410 (2293263) 2293263..2293547 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
LO742_RS11415 (2293547) 2293547..2293825 - 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO742_RS11420 (2294011) 2294011..2295021 - 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
LO742_RS11425 (2295155) 2295155..2296852 - 1698 WP_000433462.1 malate dehydrogenase -
LO742_RS11430 (2297008) 2297008..2297145 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
LO742_RS11435 (2297247) 2297247..2297462 - 216 WP_000495766.1 biofilm-dependent modulation protein -
LO742_RS11440 (2297807) 2297807..2298238 + 432 WP_000152310.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T225225 WP_000605675.1 NZ_CP087287:c2293825-2293547 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T225225 NZ_CP121075:3878163-3878420 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT225225 WP_000781370.1 NZ_CP087287:c2293547-2293263 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT225225 NZ_CP121075:c3878338-3878006 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References