Detailed information of TA system TA225216

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 703662..703920
• Replicon: chromosome
• Accession: NZ_CP087287
• Organism: Escherichia coli strain APEC 16-1068

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: LO742_RS03430
• Protein ID: WP_000809168.1
• Coordinates: 703662..703814 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	703863..703920 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LO742_RS03410	698907..699620	-	714	WP_001102393.1	acidic protein MsyB	-
LO742_RS03415	699646..700050	-	405	WP_000843687.1	DUF2541 family protein	-
LO742_RS03420	700422..702338	+	1917	WP_000516135.1	molecular chaperone DnaK	-
LO742_RS03425	702427..703557	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
LO742_RS03430	703662..703814	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	703863..703920	+	58	-	-	Antitoxin
LO742_RS03435	704426..705187	+	762	WP_001274823.1	outer membrane protein OmpK	-
LO742_RS03440	705207..706700	+	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
LO742_RS03445	706829..708088	+	1260	WP_000494924.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T225216 WP_000809168.1 NZ_CP087287:c703814-703662 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T225216 NZ_CP121075:c139383-139072 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT225216 NZ_CP087287:703863-703920 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin