Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1168103..1168752 Replicon chromosome
Accession NZ_CP087280
Organism Leclercia adecarboxylata strain SH19PE29

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LO739_RS05515 Protein ID WP_230431256.1
Coordinates 1168390..1168752 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LO739_RS05510 Protein ID WP_059308573.1
Coordinates 1168103..1168402 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO739_RS05500 (LO739_05500) 1164499..1166472 + 1974 WP_230431255.1 PhoX family phosphatase -
LO739_RS05505 (LO739_05505) 1166576..1167961 + 1386 WP_059308574.1 phenylalanine transporter -
LO739_RS05510 (LO739_05510) 1168103..1168402 - 300 WP_059308573.1 helix-turn-helix transcriptional regulator Antitoxin
LO739_RS05515 (LO739_05515) 1168390..1168752 - 363 WP_230431256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LO739_RS05520 (LO739_05520) 1169029..1170270 + 1242 WP_032616942.1 MFS transporter -
LO739_RS05525 (LO739_05525) 1170282..1171307 + 1026 WP_117385899.1 sugar phosphate isomerase/epimerase -
LO739_RS05530 (LO739_05530) 1171300..1172442 + 1143 WP_230431257.1 Gfo/Idh/MocA family oxidoreductase -
LO739_RS05535 (LO739_05535) 1172518..1173498 + 981 WP_191153075.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13958.86 Da        Isoelectric Point: 6.4838

>T225197 WP_230431256.1 NZ_CP087280:c1168752-1168390 [Leclercia adecarboxylata]
MWEVETTDTFDKWFNHQSQALKEDVLAIMHILSEYGPQLGRPWVDTVKNSHYANMKELRIQHAGDPVRAFFAFDPGRKAI
ILCAGNKTGKNEKRFYKDMITMADAEFSDYLASKEAEWLR

Download         Length: 363 bp

>T225197 NZ_CP121071:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.68 Da        Isoelectric Point: 5.8526

>AT225197 WP_059308573.1 NZ_CP087280:c1168402-1168103 [Leclercia adecarboxylata]
MATLKELMAQQSQESQERIAAKVEDLRIIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHF

Download         Length: 300 bp

>AT225197 NZ_CP121071:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References