Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3472273..3472877 Replicon chromosome
Accession NC_009943
Organism Desulfococcus oleovorans Hxd3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DOLE_RS18070 Protein ID WP_012176304.1
Coordinates 3472599..3472877 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DOLE_RS18065 Protein ID WP_012176303.1
Coordinates 3472273..3472587 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DOLE_RS14840 3467409..3468599 + 1191 WP_012176296.1 ACR3 family arsenite efflux transporter -
DOLE_RS14845 3468663..3469181 + 519 WP_012176297.1 rhodanese-like domain-containing protein -
DOLE_RS14850 3469171..3470094 + 924 WP_012176298.1 cation diffusion facilitator family transporter -
DOLE_RS14855 3470099..3470584 + 486 WP_012176299.1 DoxX family membrane protein -
DOLE_RS14860 3470581..3470982 + 402 WP_012176300.1 thioredoxin family protein -
DOLE_RS14865 3470979..3471689 + 711 WP_012176301.1 cytochrome c biosynthesis protein -
DOLE_RS14870 3471784..3472122 - 339 WP_012176302.1 YkgJ family cysteine cluster protein -
DOLE_RS18065 3472273..3472587 - 315 WP_012176303.1 HigA family addiction module antidote protein Antitoxin
DOLE_RS18070 3472599..3472877 - 279 WP_012176304.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DOLE_RS14875 3473501..3474400 - 900 WP_012176305.1 sulfite exporter TauE/SafE family protein -
DOLE_RS14880 3474572..3475255 + 684 WP_012176306.1 CerR family C-terminal domain-containing protein -
DOLE_RS14885 3475243..3476061 + 819 WP_012176307.1 DUF169 domain-containing protein -
DOLE_RS14890 3476132..3477325 + 1194 WP_012176308.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10683.02 Da        Isoelectric Point: 8.4739

>T22517 WP_012176304.1 NC_009943:c3472877-3472599 [Desulfococcus oleovorans Hxd3]
MIKSFKHKGLEDFFYSGKKKGIRPEHADRLSRILDRLNAANEVMDMNYPGSNLHKLSGNLQGQFSVHVSGNWRVFFQFVD
GDAYIVNYDDYH

Download         Length: 279 bp

>T22517 NC_009943:c3472877-3472599 [Desulfococcus oleovorans Hxd3]
ATGATTAAATCATTCAAGCATAAAGGCCTTGAAGATTTCTTTTATTCTGGAAAGAAAAAGGGCATCCGACCAGAACATGC
AGATAGACTTTCCAGAATTTTAGACCGGTTAAATGCGGCAAATGAGGTTATGGATATGAATTATCCCGGATCAAATTTAC
ATAAACTGTCTGGAAATTTACAAGGCCAGTTTTCTGTGCATGTTTCTGGAAACTGGAGAGTATTTTTTCAATTTGTAGAC
GGTGATGCTTATATCGTTAACTATGACGATTACCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12060.02 Da        Isoelectric Point: 10.8791

>AT22517 WP_012176303.1 NC_009943:c3472587-3472273 [Desulfococcus oleovorans Hxd3]
MKRIQRKPSHPGSILREDYLKPLSITVTDMASKLNVSRKTLSKILNEKGAVTPDMALRLSRAFNTTPELWLNLQKNVDLW
EAENLSRDWRRVRPLPEKALHSEL

Download         Length: 315 bp

>AT22517 NC_009943:c3472587-3472273 [Desulfococcus oleovorans Hxd3]
ATGAAAAGAATTCAGCGAAAACCTTCCCATCCTGGATCCATACTGCGAGAAGACTATCTAAAGCCATTATCAATAACGGT
AACTGATATGGCGTCAAAATTGAATGTGTCGAGAAAAACGCTATCTAAAATACTGAATGAAAAAGGTGCGGTAACGCCGG
ATATGGCTTTGCGGCTATCAAGAGCTTTCAACACCACCCCCGAATTATGGCTGAATTTGCAAAAGAACGTCGACCTTTGG
GAAGCTGAGAATTTATCCAGAGACTGGCGCCGTGTTCGTCCTCTTCCAGAAAAAGCACTGCATTCTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References