Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5475028..5475608 Replicon chromosome
Accession NZ_CP087203
Organism Pseudomonas sp. B21-056

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY67_RS23845 Protein ID WP_265067820.1
Coordinates 5475028..5475306 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY67_RS23850 Protein ID WP_092459784.1
Coordinates 5475321..5475608 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY67_RS23830 (LOY67_23805) 5471117..5473318 - 2202 WP_265064707.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LOY67_RS23835 (LOY67_23810) 5473318..5474304 - 987 WP_265064708.1 xanthine dehydrogenase family protein subunit M -
LOY67_RS23840 (LOY67_23815) 5474301..5474825 - 525 WP_055129692.1 (2Fe-2S)-binding protein -
LOY67_RS23845 (LOY67_23820) 5475028..5475306 + 279 WP_265067820.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY67_RS23850 (LOY67_23825) 5475321..5475608 + 288 WP_092459784.1 HigA family addiction module antitoxin Antitoxin
LOY67_RS23855 (LOY67_23830) 5475615..5476181 - 567 WP_265064709.1 DJ-1/PfpI family protein -
LOY67_RS23860 (LOY67_23835) 5476331..5476753 - 423 WP_265067821.1 YolA family protein -
LOY67_RS23865 (LOY67_23840) 5476988..5478283 + 1296 WP_265064710.1 NCS2 family permease -
LOY67_RS23870 (LOY67_23845) 5478280..5479359 + 1080 WP_265064711.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
LOY67_RS23875 (LOY67_23850) 5479670..5480110 + 441 WP_047702651.1 type II 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10838.44 Da        Isoelectric Point: 9.5306

>T225132 WP_265067820.1 NZ_CP087203:5475028-5475306 [Pseudomonas sp. B21-056]
MIKSFQHKGLRIFYETGSTRGIRADHGKRLARMLQFMDRATVPNDLDVPGWRLHPLRGELAEYWSLSVSGNWRIIFRFIG
SDIELVDYLDYH

Download         Length: 279 bp

>T225132 NZ_CP121003:310519-310887 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10677.32 Da        Isoelectric Point: 6.6041

>AT225132 WP_092459784.1 NZ_CP087203:5475321-5475608 [Pseudomonas sp. B21-056]
MPMHNPPHPGETLLMDVLPELGITVTELARHLGFARPHLSRVLHGHAPVSPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EQREQPLIEPFLQHA

Download         Length: 288 bp

>AT225132 NZ_CP121003:310301-310522 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References