Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4289411..4290015 Replicon chromosome
Accession NZ_CP087203
Organism Pseudomonas sp. B21-056

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY67_RS18215 Protein ID WP_265063816.1
Coordinates 4289411..4289725 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY67_RS18220 Protein ID WP_265063817.1
Coordinates 4289728..4290015 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY67_RS18195 (LOY67_18170) 4285820..4286062 - 243 WP_265063812.1 hypothetical protein -
LOY67_RS18200 (LOY67_18175) 4286177..4287520 + 1344 WP_265063813.1 chromate efflux transporter -
LOY67_RS18205 (LOY67_18180) 4287517..4287948 - 432 WP_265063814.1 arsenic resistance N-acetyltransferase ArsN2 -
LOY67_RS18210 (LOY67_18185) 4288143..4289297 + 1155 WP_265063815.1 mechanosensitive ion channel family protein -
LOY67_RS18215 (LOY67_18190) 4289411..4289725 + 315 WP_265063816.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY67_RS18220 (LOY67_18195) 4289728..4290015 + 288 WP_265063817.1 helix-turn-helix domain-containing protein Antitoxin
LOY67_RS18225 (LOY67_18200) 4290313..4290792 + 480 WP_265063818.1 hypothetical protein -
LOY67_RS18230 (LOY67_18205) 4290803..4291051 - 249 WP_265063819.1 hypothetical protein -
LOY67_RS18235 (LOY67_18210) 4291428..4292891 - 1464 WP_265063820.1 aspartate/glutamate racemase family protein -
LOY67_RS18240 (LOY67_18215) 4292903..4294198 - 1296 WP_265063821.1 dicarboxylate/amino acid:cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4289411..4297568 8157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11846.63 Da        Isoelectric Point: 9.8325

>T225131 WP_265063816.1 NZ_CP087203:4289411-4289725 [Pseudomonas sp. B21-056]
MIFIETPIFTRRANELMNDDDYSTLQATLVRNPSAGDVIEATGGIRKIRIAAKGHGKRGGARVIYYHFVADSQIALLMIY
PKNEQQDLTVDQRKAMKTIVEHWR

Download         Length: 315 bp

>T225131 NZ_CP121003:200447-200932 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10697.35 Da        Isoelectric Point: 10.1758

>AT225131 WP_265063817.1 NZ_CP087203:4289728-4290015 [Pseudomonas sp. B21-056]
MSKFFDELMESVQQMDEIVRGERQPSRKFVVDALQVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRRAPTGPARALLR
AIHNDPEHVISALAV

Download         Length: 288 bp

>AT225131 NZ_CP121003:200172-200459 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References