Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 519771..520465 Replicon chromosome
Accession NZ_CP087201
Organism Pseudomonas sp. B21-059

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY69_RS02385 Protein ID WP_213664620.1
Coordinates 519771..520067 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY69_RS02390 Protein ID WP_102882058.1
Coordinates 520064..520465 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY69_RS02360 (LOY69_02360) 515717..516487 + 771 WP_102882064.1 ParA family protein -
LOY69_RS02365 (LOY69_02365) 516535..516969 - 435 WP_102882063.1 thioredoxin TrxC -
LOY69_RS02370 (LOY69_02370) 517048..517998 - 951 WP_265074087.1 hypothetical protein -
LOY69_RS02375 (LOY69_02375) 518025..518969 - 945 WP_265074088.1 hypothetical protein -
LOY69_RS02380 (LOY69_02380) 519046..519486 - 441 WP_110651000.1 IgaA/UmoB family intracellular growth attenuator -
LOY69_RS02385 (LOY69_02385) 519771..520067 + 297 WP_213664620.1 type II toxin-antitoxin system HigB family toxin Toxin
LOY69_RS02390 (LOY69_02390) 520064..520465 + 402 WP_102882058.1 transcriptional regulator Antitoxin
LOY69_RS02395 (LOY69_02395) 520467..521930 - 1464 WP_265074089.1 YdiU family protein -
LOY69_RS02400 (LOY69_02400) 521980..525333 - 3354 WP_102882056.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11433.27 Da        Isoelectric Point: 10.6515

>T225119 WP_213664620.1 NZ_CP087201:519771-520067 [Pseudomonas sp. B21-059]
MHIITAKRIRQAKEQWPQVARALDTWYRKAKGARPADFADMKALFPALDKVGRFHVFDIGGNKLRLIAIVRYGGQRLYIR
HVLDHGEYDKGLWKEESQ

Download         Length: 297 bp

>T225119 NZ_CP120975:c130241-129909 [Moellerella wisconsensis]
ATGGTATCTCGATACGTACCTGATTCTGGCGATTTGATTTGGATTGACTTTGATCCAGTTGAAGGACATGAGCAGGGCGG
TCATCGTCCAGCAGTTGTCCTTAGCCCTTTTGCATACAATAATAAAGTAGGGCTCTTACTATGCGTACCATGTACAACTA
AAGGCAAAGGCTATCCATTTGAATGCGAACTCTCGAACGAAAGAGACAGCTACGCATTAGCGGATCAAGTTACATGTGTT
GACTGGAGAGCTCGTAAAGTTACTAAAAAGGGCAAAGTGGAGGCATCAGAACTGGCAGAGATAAAAGCTAAAGCAAAGGC
GTTAATAGGATAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14919.02 Da        Isoelectric Point: 4.5603

>AT225119 WP_102882058.1 NZ_CP087201:520064-520465 [Pseudomonas sp. B21-059]
MSLQVKQAAEHWQFVAPILRKPKSEADYDALALALDELLDIMGEDESHPLASLVDIIGDWIEAYDEEHHPMPAVSAVEVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFKVSMETFA

Download         Length: 402 bp

>AT225119 NZ_CP120975:c130486-130241 [Moellerella wisconsensis]
ATGGCTCAGGTCACAGTAAAAAAATGGGGCAATAGCCCGTCTGTACGGCTTCCTGTTGCTATCATGCAAAAAGCGGCACT
TAGCGTTGATGATACGGTTGAAATAGCGGTAGAAGAAGGTCGTATCATCATTACGCCAGTTAAAGCGGTAGAATACTCAT
TAGATAATTTGTTAGCCGGTATCACACCGGAGAATATCCATGAGAAAGTAGACTTCGGAGCTCGAACAGGTAAGGAATTA
ATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References