Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5428799..5429453 Replicon chromosome
Accession NZ_CP087197
Organism Pseudomonas sp. B21-012

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY37_RS24995 Protein ID WP_258715940.1
Coordinates 5428799..5429137 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY37_RS25000 Protein ID WP_258608324.1
Coordinates 5429139..5429453 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY37_RS24970 (LOY37_24945) 5425694..5426116 - 423 WP_258715937.1 type II toxin-antitoxin system HicB family antitoxin -
LOY37_RS24975 (LOY37_24950) 5426185..5426358 - 174 WP_258717225.1 type II toxin-antitoxin system HicA family toxin -
LOY37_RS24980 (LOY37_24955) 5426426..5427214 - 789 WP_258715938.1 helix-turn-helix transcriptional regulator -
LOY37_RS24985 (LOY37_24960) 5427308..5428126 + 819 WP_258715939.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
LOY37_RS24990 (LOY37_24965) 5428219..5428680 + 462 WP_038998420.1 Lrp/AsnC family transcriptional regulator -
LOY37_RS24995 (LOY37_24970) 5428799..5429137 + 339 WP_258715940.1 toxin Toxin
LOY37_RS25000 (LOY37_24975) 5429139..5429453 + 315 WP_258608324.1 transcriptional regulator Antitoxin
LOY37_RS25005 (LOY37_24980) 5429614..5431296 + 1683 WP_045199243.1 NAD(P)/FAD-dependent oxidoreductase -
LOY37_RS25010 (LOY37_24985) 5431310..5432107 + 798 WP_093378922.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13043.94 Da        Isoelectric Point: 9.7600

>T225107 WP_258715940.1 NZ_CP087197:5428799-5429137 [Pseudomonas sp. B21-012]
MDALFVELPAFARYRSDYLDDEAMRALQLVLLLNPQAGSVIQGTGGLRKVRFADDQRHKGKRGGIRVIYYWWSNGQQFWL
FTLYGKDQLDDLSPAQRHSLKQMLDLQIEARR

Download         Length: 339 bp

>T225107 NZ_CP120970:2876834-2877058 [Moellerella wisconsensis]
ATGAATGAAAGACAGGAAAATATGACTAAAACAGACTATCTGATGCGTTTAAGAAAATGCACGACTATTGAAACATTAGA
GCGTGTTATTGAAAAAAATAAATATGAGCTATCTGATGATGAACTCGAACTGTTTTTTTCCGCTGCTGACCATCGTCTAG
CAGAACTAACAATGAATAAACTGTATGACAAAATTCCAGCATCTGTCTGGAAATATGTTCGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11941.75 Da        Isoelectric Point: 7.2065

>AT225107 WP_258608324.1 NZ_CP087197:5429139-5429453 [Pseudomonas sp. B21-012]
MKRDVFSELNEGFDALAQERQGKLTLRSHKVQLAELMDVSAEELVAIRERLNMSRAVFAMYLRTNARTLENWEQGRARPN
AQAMTLIRLVEKFPETVEHLAALA

Download         Length: 315 bp

>AT225107 NZ_CP120970:2876419-2876787 [Moellerella wisconsensis]
ATGGATGAATATTCACCCAGATATTACGATACTGCTGAATTAAAGTATTTATGTGATAGCCTTAACAATGATGCGATATT
ATCGCTACATAAGACTAAAACGCATTGGATTAATGATTTAAGTTCACAGCAAAGTACGAATTTGAATGAGTTAATAGAGC
ATGTGGCTGCATTTTTTTGGAAATTTAAGATAAAATACCCTAGTGAACGCTTAGTCATCTCTCTAGTTGATGAATATCTT
GATGAAACTTATAATTTATTTGGTAGTCCATTAATCACATTAAATGAATTTTCAGATTGGCAAAAAATGAATACTCACTT
AATTGATGAATTAAATAACGATTTAAAGTGTTCAGTAGCCAAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References