Detailed information of TA system TA225091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 4026327..4026981
• Replicon: chromosome
• Accession: NZ_CP087193
• Organism: Pseudomonas sp. B21-019

Toxin (Protein)

• Gene name: higB
• Uniprot ID: J2N4P4
• Locus tag: LOY36_RS17915
• Protein ID: WP_007940886.1
• Coordinates: 4026327..4026677 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LOY36_RS17920
• Protein ID: WP_007940887.1
• Coordinates: 4026667..4026981 (+)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY36_RS17895 (LOY36_17875)	4022023..4023555	+	1533	WP_018925506.1	NADH-quinone oxidoreductase subunit M	-
LOY36_RS17900 (LOY36_17880)	4023563..4025026	+	1464	WP_007940882.1	NADH-quinone oxidoreductase subunit NuoN	-
LOY36_RS17905 (LOY36_17885)	4025196..4025483	+	288	WP_258669455.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
LOY36_RS17910 (LOY36_17890)	4025489..4025953	-	465	WP_258669459.1	GNAT family N-acetyltransferase	-
LOY36_RS17915 (LOY36_17895)	4026327..4026677	+	351	WP_007940886.1	toxin	Toxin
LOY36_RS17920 (LOY36_17900)	4026667..4026981	+	315	WP_007940887.1	transcriptional regulator	Antitoxin
LOY36_RS17925 (LOY36_17905)	4027158..4028483	+	1326	WP_258669463.1	OprD family porin	-
LOY36_RS17930 (LOY36_17910)	4028691..4029071	-	381	WP_258669466.1	DUF6124 family protein	-
LOY36_RS17935 (LOY36_17915)	4029440..4029772	-	333	WP_258669469.1	DUF2790 domain-containing protein	-
LOY36_RS17940 (LOY36_17920)	4029852..4030052	-	201	WP_018925500.1	co-regulatory protein PtrA N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (41-100)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13975.72 Da
• Isoelectric Point: 7.2019

>T225091 WP_007940886.1 NZ_CP087193:4026327-4026677 [Pseudomonas sp. B21-019]
MDALFIELPAFQKHRDDYLDDDLFRSFQLELLKNPEAGDLIEGTGGLRKIRFFDQRRGKGKRSGLRVIYYWWSGFDQFWL
FTVYSKNEQDDLSPSQKKLFRQTLDREINTRTHYET

Nucleotide

• Length: 351 bp

>T225091 NZ_CP120956:596992-597846 [Delftia tsuruhatensis]
ATGACCGCGCAGACGCTGCAACGCATGGAGCAGCGCCTTCAGGCGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGTGG
CGCCCAGGTCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCGTCCTGGATGGATGTGGCCCTGGCGCTGGCGCCGCGCACGCGTGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACGCCGCTGGCACCCGCCGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCTCTGCAGGAAAAAGGCATCGAAGGCCTGGCTGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCCGCAGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGAGGGGCGCCTTGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTGGTC
ACGCCGCCGGCCGCCTGCGCGGCCTGGGCCGCAAGACTGGGGGCGCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11904.82 Da
• Isoelectric Point: 10.3437

>AT225091 WP_007940887.1 NZ_CP087193:4026667-4026981 [Pseudomonas sp. B21-019]
MKRDIFSELMEGLEALADERQGKVTLRTHKVKLPKLVPITAEEVVAIRQQLNLSRSVFAMYLRTNTRTLENWEQGRATPN
AQATTLIRLVERFPQTIEQLAALT

Nucleotide

• Length: 315 bp

>AT225091 NZ_CP120956:597869-598675 [Delftia tsuruhatensis]
ATGAGCGATACCTCCGAAACCCTCTCCACCGACAACGACCGCTACACCGTTCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCGCGTTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGGGCATGGGGTATCTGCAACGCTCGGGCACCGAATACCGGCTGGGCCTGGCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGTCGCTGTGCGACCGGCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCCGTGGTCTACGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGGCTGCCGGCCCATGCCACCGTGCTGGGCCGGGCACTGCTGCAGGACATGGACGCG
GACCAGCTGCGCGCCCTGTTCGGCGGCAGCGAACTGCCCCAGTTCTCGGAAAGCACGCCGCGCAGCGTGGAACAGTTGCT
GCAGTTGCTGCAGCAGGACCATGAACGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATCGCCG
CGCCTGTGCGCGATGCGCAGGGGCGCATCGTGGCGGGCCTGGGCATGGCCGTGGCCTTCACCGAAATCGCTCCCGGCCGC
ATGGCCGACTGGGTGGAGCAGGTACGTGCCGCCGCCGATGAGCTGGCCGGCCACCTGCGCACCCAGCATCCCGGTTTTCT
GCGCTGA

Structures

Toxin

• AlphaFold DB: J2N4P4