Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1058510..1059165 Replicon chromosome
Accession NZ_CP087188
Organism Pseudomonas laurylsulfatiphila strain B21-025

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY25_RS04595 Protein ID WP_033047368.1
Coordinates 1058510..1058854 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY25_RS04600 Protein ID WP_007970375.1
Coordinates 1058851..1059165 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY25_RS04570 (LOY25_04560) 1053527..1054462 + 936 WP_218480044.1 ubiquinol oxidase subunit II -
LOY25_RS04575 (LOY25_04565) 1054466..1056496 + 2031 WP_007970371.1 cytochrome o ubiquinol oxidase subunit I -
LOY25_RS04580 (LOY25_04570) 1056500..1057126 + 627 WP_102701088.1 cytochrome o ubiquinol oxidase subunit III -
LOY25_RS04585 (LOY25_04575) 1057127..1057474 + 348 WP_007970373.1 cytochrome o ubiquinol oxidase subunit IV -
LOY25_RS04590 (LOY25_04580) 1057486..1058373 + 888 WP_218482408.1 heme o synthase -
LOY25_RS04595 (LOY25_04585) 1058510..1058854 + 345 WP_033047368.1 hypothetical protein Toxin
LOY25_RS04600 (LOY25_04590) 1058851..1059165 + 315 WP_007970375.1 helix-turn-helix domain-containing protein Antitoxin
LOY25_RS04605 (LOY25_04595) 1059225..1059503 - 279 WP_015093561.1 DUF3077 domain-containing protein -
LOY25_RS04610 (LOY25_04600) 1060127..1061545 - 1419 WP_258684096.1 PLP-dependent aminotransferase family protein -
LOY25_RS04615 (LOY25_04605) 1061696..1062796 + 1101 WP_258684098.1 hypothetical protein -
LOY25_RS04620 (LOY25_04610) 1062839..1064119 + 1281 WP_258684100.1 biotin carboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-94)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13302.16 Da        Isoelectric Point: 9.9314

>T225071 WP_033047368.1 NZ_CP087188:1058510-1058854 [Pseudomonas laurylsulfatiphila]
MRTVFFETTSFTATVGNYLTDDEYRALQSHMQLNPQAGDVMPRTGGFRKLRWADGRRGKGRRGGLRVIYYWLMNDGQFWM
FAIYDKDELENLTADQEKVLKKAIETELKKRGTP

Download         Length: 345 bp

>T225071 NZ_CP120944:4725610-4725951 [Escherichia coli O157:H7 str. EDL933]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11798.77 Da        Isoelectric Point: 9.9443

>AT225071 WP_007970375.1 NZ_CP087188:1058851-1059165 [Pseudomonas laurylsulfatiphila]
MKKRDLFAELMQGVDEMAAQREGKITLRNTVVEDIPAPEVGAQEIVALREKLHMSQAVFAKRIRTSPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVDRLAVV

Download         Length: 315 bp

>AT225071 NZ_CP120944:c4725615-4725539 [Escherichia coli O157:H7 str. EDL933]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References