Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1159828..1160432 Replicon chromosome
Accession NZ_CP087185
Organism Pseudomonas sichuanensis strain B21-027

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY51_RS05405 Protein ID WP_258645120.1
Coordinates 1160112..1160432 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY51_RS05400 Protein ID WP_125462792.1
Coordinates 1159828..1160115 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY51_RS05375 (LOY51_05375) 1155806..1156414 + 609 WP_258645115.1 hypothetical protein -
LOY51_RS05380 (LOY51_05380) 1156514..1157734 + 1221 WP_125857590.1 SAM-dependent methyltransferase -
LOY51_RS05385 (LOY51_05385) 1157939..1158175 + 237 WP_223811926.1 hypothetical protein -
LOY51_RS05390 (LOY51_05390) 1158178..1158687 + 510 WP_125857591.1 DNA-binding protein -
LOY51_RS05395 (LOY51_05395) 1158710..1159720 - 1011 WP_258645118.1 DUF4917 family protein -
LOY51_RS05400 (LOY51_05400) 1159828..1160115 - 288 WP_125462792.1 NadS family protein Antitoxin
LOY51_RS05405 (LOY51_05405) 1160112..1160432 - 321 WP_258645120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY51_RS05410 (LOY51_05410) 1160564..1162264 - 1701 WP_258645122.1 SulP family inorganic anion transporter -
LOY51_RS05420 (LOY51_05420) 1162656..1163540 - 885 WP_125462795.1 alpha/beta hydrolase -
LOY51_RS05425 (LOY51_05425) 1163988..1164680 - 693 WP_125857594.1 16S rRNA pseudouridine(516) synthase -
LOY51_RS05430 (LOY51_05430) 1164712..1164933 - 222 WP_125462797.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12077.88 Da        Isoelectric Point: 10.1563

>T225046 WP_258645120.1 NZ_CP087185:c1160432-1160112 [Pseudomonas sichuanensis]
MLFTETAVFTKRAKELLDDETYRLLQVRLLISPDAGDVIEGTGGLRKIRAPANGHGKRGGARVIYYHFTARSHITLLYIF
AKNEQSELSAEQRKALKSVIENWRYP

Download         Length: 321 bp

>T225046 NZ_CP120920:571274-571624 [Bacillus paralicheniformis]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.55 Da        Isoelectric Point: 6.7284

>AT225046 WP_125462792.1 NZ_CP087185:c1160115-1159828 [Pseudomonas sichuanensis]
MSRLFDELMESVVEMDEIIQGKRQPSRQFEIDALQVREIRKATGLSQVRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIHNDPDHVLKALSH

Download         Length: 288 bp

>AT225046 NZ_CP120920:570988-571269 [Bacillus paralicheniformis]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References