Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4499751..4500451 Replicon chromosome
Accession NZ_CP087183
Organism Pseudomonas putida strain B21-029

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7H5R7B0
Locus tag LOY24_RS20240 Protein ID WP_063423101.1
Coordinates 4500155..4500451 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A7H5R787
Locus tag LOY24_RS20235 Protein ID WP_063423100.1
Coordinates 4499751..4500152 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY24_RS20215 (LOY24_20195) 4494888..4495709 - 822 WP_258653423.1 transporter substrate-binding domain-containing protein -
LOY24_RS20220 (LOY24_20200) 4495785..4496714 - 930 WP_028613362.1 FAD-binding protein -
LOY24_RS20225 (LOY24_20205) 4496715..4497464 - 750 WP_028613363.1 electron transfer flavoprotein subunit beta/FixA family protein -
LOY24_RS20230 (LOY24_20210) 4497997..4499679 + 1683 WP_258653424.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
LOY24_RS20235 (LOY24_20215) 4499751..4500152 - 402 WP_063423100.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LOY24_RS20240 (LOY24_20220) 4500155..4500451 - 297 WP_063423101.1 type II toxin-antitoxin system MqsR family toxin Toxin
LOY24_RS20245 (LOY24_20225) 4500546..4501871 - 1326 WP_258653425.1 MFS transporter -
LOY24_RS20250 (LOY24_20230) 4501945..4502424 - 480 WP_258653426.1 histidine kinase -
LOY24_RS20255 (LOY24_20235) 4502593..4503069 - 477 WP_016498679.1 sigma-70 family RNA polymerase sigma factor -
LOY24_RS20260 (LOY24_20240) 4503311..4504483 + 1173 WP_258653427.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-96)

Antitoxin

Zinc finger, MqsA-type

(3-46)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11020.94 Da        Isoelectric Point: 9.7531

>T225040 WP_063423101.1 NZ_CP087183:c4500451-4500155 [Pseudomonas putida]
MEKRTPHCPLERVKVLAAARRISPTGAALRGAKALGIDYPGMLEVISSLERTDFYKSMTSHMDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKGL

Download         Length: 297 bp

>T225040 NZ_CP120848:37158-37649 [Klebsiella pneumoniae]
GTGGGCAAAGTAACGGCTCCGGTCCCACTCGGTACGTCACACATCCTCGCTGAGTTTCACTGTGGTGAGCCTGTACTGGA
CGAATGGATAAAGCACCGGGGACTAAAAAATCAGTCCCTGGGGGCGGCCAGAACGTTTGTGGTGTGCCGGGGAAATGCTT
CACAGGTGCTTGCCTACTACTCTCTCGCGACCGGCAGCGTCACTCATGCCATTGCGCCGGGAAGCCTGCGAAGGAATATG
CCCGATCCTGTACCTGTCATCATCCTGGCCCGTCTTGCTGTCGATACGAGTTATCACGGCCAGGGACTGGGGGCTGATTT
ACTGCATGATGCCGTATTACGTTGCTGTCGGGTGGCTGAGAACATTGGCGTGCGGGCCGTTATGGTTCATGCACTCTCTG
ACAGTGCCAGACAGTTCTACATACATCACGGATTTATCCCTTCACAAACGCAGGATAGAACCCTTTTTTTACGGTTGCCT
CTCATTACTTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14562.59 Da        Isoelectric Point: 4.7452

>AT225040 WP_063423100.1 NZ_CP087183:c4500152-4499751 [Pseudomonas putida]
MRCPICGGAELAPDVQGMPYSYKGEATVIPDVSGDYCSACGECVLSHDEAMRISNLMTAFDRQVNATVVDPSFIASMRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp

>AT225040 NZ_CP120848:36904-37170 [Klebsiella pneumoniae]
ATGAAATCTGATGTTCAGCTCAACATCCGGGCGAAAGAAGCCCAGCGGGCTCTGATTGATACTGCCGCTGAGATTCTCCA
CAAATCACGCACTGATTTTATACTGGAGATGGCCTGTCAGGCGGCGGAAAACGTCATTCTTGACCGCCGTATGTTCAATC
TCAATGATGAACAGTACGCCGAGTTTATCGACATGCTGGATGCGCCGGTCACCGCTAACCCGGCGATGGAGAAACTCCTG
GCGAGAAAACCGCAGTGGGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5R7B0

Antitoxin

Source ID Structure
AlphaFold DB A0A7H5R787

References