22503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6012325..6012928 Replicon chromosome
Accession NC_009925
Organism Acaryochloris marina MBIC11017

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag AM1_RS26805 Protein ID WP_041660594.1
Coordinates 6012325..6012609 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag AM1_RS26810 Protein ID WP_012166089.1
Coordinates 6012617..6012928 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AM1_RS26780 6008231..6009121 - 891 WP_148215839.1 inositol monophosphatase family protein -
AM1_RS26785 6009198..6010943 + 1746 WP_012166084.1 ABC transporter ATP-binding protein/permease -
AM1_RS26790 6011048..6011386 + 339 WP_012166085.1 hypothetical protein -
AM1_RS42925 6011419..6011640 + 222 WP_012166086.1 N-acetyltransferase -
AM1_RS26800 6011902..6012204 + 303 WP_041660592.1 hypothetical protein -
AM1_RS26805 6012325..6012609 + 285 WP_041660594.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AM1_RS26810 6012617..6012928 + 312 WP_012166089.1 HigA family addiction module antidote protein Antitoxin
AM1_RS26815 6013005..6013490 - 486 WP_012166090.1 hypothetical protein -
AM1_RS42930 6013953..6014258 - 306 Protein_5325 transposase -
AM1_RS26825 6014290..6014826 - 537 WP_049783712.1 helix-turn-helix domain-containing protein -
AM1_RS26830 6015059..6015295 - 237 WP_012166091.1 thioredoxin family protein -
AM1_RS26835 6015446..6015766 + 321 WP_012166092.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(13-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(9-84)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10902.54 Da        Isoelectric Point: 9.4238

>T22503 WP_041660594.1 NC_009925:6012325-6012609 [Acaryochloris marina MBIC11017]
MIVRFSSKETKLIFYGYTSRVYPPDIQKIALRKLLILDAAASVDDLRIPPGNRLEKLAGDRKGQYSIRINSQWRICFTWT
AENNADQVEIVDYH

Download         Length: 285 bp

>T22503 NC_009925:6012325-6012609 [Acaryochloris marina MBIC11017]
ATGATAGTAAGGTTTAGCTCCAAAGAAACGAAGCTTATCTTCTATGGCTACACATCTCGTGTATATCCACCTGATATCCA
AAAGATTGCGTTACGCAAACTCCTCATACTTGATGCCGCGGCATCAGTGGATGATTTGCGTATTCCTCCAGGAAATCGAT
TAGAGAAGCTAGCGGGAGATCGTAAAGGACAATACAGCATCCGTATCAATAGCCAATGGCGAATCTGCTTTACCTGGACA
GCAGAAAATAATGCCGATCAAGTTGAAATCGTTGATTACCATTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11656.28 Da        Isoelectric Point: 7.2000

>AT22503 WP_012166089.1 NC_009925:6012617-6012928 [Acaryochloris marina MBIC11017]
MENGRLPIIHPGEILKLEFLEPLDLTPYRLSKDIGVAQTRISEILSGKRSITADTALRLSQYFGNSAQFWLNLQTQYDLR
QAQEANRGVYSQIPTIQLAHLSS

Download         Length: 312 bp

>AT22503 NC_009925:6012617-6012928 [Acaryochloris marina MBIC11017]
ATGGAAAACGGTCGTCTGCCAATTATTCACCCTGGAGAAATCTTAAAACTAGAGTTTCTTGAGCCGCTGGATCTCACGCC
ATATCGTTTAAGTAAGGATATTGGTGTTGCTCAAACCAGAATTAGCGAAATATTGTCTGGGAAGCGTAGTATTACTGCTG
ATACAGCCCTTCGTCTATCTCAGTATTTTGGCAACAGCGCTCAATTCTGGTTGAACTTACAGACACAATATGATTTACGC
CAAGCTCAGGAAGCCAATAGAGGTGTATACAGCCAAATTCCAACCATACAACTTGCTCACCTGTCATCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References