225017

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5201501..5202081 Replicon chromosome
Accession NZ_CP087177
Organism Pseudomonas moraviensis strain B21-039

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY57_RS22795 Protein ID WP_258641496.1
Coordinates 5201501..5201779 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY57_RS22800 Protein ID WP_016773085.1
Coordinates 5201794..5202081 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY57_RS22775 (LOY57_22730) 5197077..5197244 - 168 WP_016773090.1 DUF2474 domain-containing protein -
LOY57_RS22780 (LOY57_22735) 5197329..5198336 - 1008 WP_042610525.1 cytochrome d ubiquinol oxidase subunit II -
LOY57_RS22785 (LOY57_22740) 5198340..5199785 - 1446 WP_042610526.1 cytochrome ubiquinol oxidase subunit I -
LOY57_RS22790 (LOY57_22745) 5200166..5201401 + 1236 WP_042610527.1 MFS transporter -
LOY57_RS22795 (LOY57_22750) 5201501..5201779 + 279 WP_258641496.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY57_RS22800 (LOY57_22755) 5201794..5202081 + 288 WP_016773085.1 HigA family addiction module antitoxin Antitoxin
LOY57_RS22805 (LOY57_22760) 5202086..5202637 - 552 WP_064364090.1 DJ-1/PfpI family protein -
LOY57_RS22810 (LOY57_22765) 5202705..5203151 - 447 WP_083353609.1 DUF4879 domain-containing protein -
LOY57_RS22815 (LOY57_22770) 5203372..5204667 + 1296 WP_064364088.1 NCS2 family permease -
LOY57_RS22820 (LOY57_22775) 5204664..5205743 + 1080 WP_258639292.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
LOY57_RS22825 (LOY57_22780) 5205798..5206244 - 447 WP_064364086.1 DUF2442 domain-containing protein -
LOY57_RS22830 (LOY57_22785) 5206241..5206669 - 429 WP_258639295.1 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10815.35 Da        Isoelectric Point: 8.5218

>T225017 WP_258641496.1 NZ_CP087177:5201501-5201779 [Pseudomonas moraviensis]
MIKSFQHKGLRGFYETGTTRGIRADHAKRLSRMLQFMDRATLPGDLDLPGWRLHPLKGELSEYWSLSVSDNWRVIFRFVG
SDIELVDYLDYH

Download         Length: 279 bp

>T225017 NZ_CP120837:c2693325-2693222 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10525.13 Da        Isoelectric Point: 6.6962

>AT225017 WP_016773085.1 NZ_CP087177:5201794-5202081 [Pseudomonas moraviensis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG

Download         Length: 288 bp

>AT225017 NZ_CP120837:2693220-2693365 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References