Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 3602430..3603088 Replicon chromosome
Accession NZ_CP087170
Organism Pseudomonas rhodesiae strain B21-046

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY39_RS16120 Protein ID WP_034099048.1
Coordinates 3602744..3603088 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY39_RS16115 Protein ID WP_258694809.1
Coordinates 3602430..3602747 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY39_RS16095 (LOY39_16075) 3600343..3601194 - 852 WP_034099041.1 hypothetical protein -
LOY39_RS16100 (LOY39_16080) 3601414..3601533 + 120 Protein_3171 IS5/IS1182 family transposase -
LOY39_RS16105 (LOY39_16085) 3601618..3601854 - 237 WP_034099043.1 YdaS family helix-turn-helix protein -
LOY39_RS16110 (LOY39_16090) 3601953..3602378 + 426 WP_005789662.1 helix-turn-helix domain-containing protein -
LOY39_RS16115 (LOY39_16095) 3602430..3602747 - 318 WP_258694809.1 transcriptional regulator Antitoxin
LOY39_RS16120 (LOY39_16100) 3602744..3603088 - 345 WP_034099048.1 toxin Toxin
LOY39_RS16125 (LOY39_16105) 3603211..3604014 - 804 WP_034099050.1 phage antirepressor KilAC domain-containing protein -
LOY39_RS16130 (LOY39_16110) 3604011..3604322 - 312 WP_258694810.1 DUF3077 domain-containing protein -
LOY39_RS16135 (LOY39_16115) 3604396..3604551 - 156 WP_258694811.1 Arc family DNA-binding protein -
LOY39_RS16140 (LOY39_16120) 3604696..3605082 + 387 WP_258694812.1 helix-turn-helix transcriptional regulator -
LOY39_RS16145 (LOY39_16125) 3605332..3606249 - 918 WP_258694813.1 hypothetical protein -
LOY39_RS16150 (LOY39_16130) 3606450..3606923 + 474 WP_034099054.1 hypothetical protein -
LOY39_RS16155 (LOY39_16135) 3607029..3607316 + 288 WP_034099056.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LOY39_RS16160 (LOY39_16140) 3607306..3607593 + 288 WP_034099058.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3595243..3612752 17509
- flank IS/Tn - - 3601414..3601536 122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(46-95)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13141.93 Da        Isoelectric Point: 9.6563

>T224984 WP_034099048.1 NZ_CP087170:c3603088-3602744 [Pseudomonas rhodesiae]
MKTVFFETTSFTATVGDYLTDDEYRQLQTEMQANPEAGDVMPRTGGFRKLRWQDTRRGKGKRGGLRVIYYWLLNDGQFWM
FSIYDKDEMANLTAAQEKALKAAIDAELKKRGGK

Download         Length: 345 bp

>T224984 NZ_CP120681:1638324-1638440 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12056.96 Da        Isoelectric Point: 10.1426

>AT224984 WP_258694809.1 NZ_CP087170:c3602747-3602430 [Pseudomonas rhodesiae]
MKKKRDLFAELMQGVNEMGEHRQGKITLRQYEVEALSPPEVTAAEIVSIRENLHMSQPVFARQIRTSPDTLKNWEQSKSK
PNAQAALLIKLVQRFPDMVERLNAV

Download         Length: 318 bp

>AT224984 NZ_CP120681:c1638614-1638435 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References