Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1235160..1235746 Replicon chromosome
Accession NZ_CP087169
Organism Pseudomonas sp. B21-047

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag LOY26_RS05670 Protein ID WP_186654474.1
Coordinates 1235468..1235746 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LOY26_RS05665 Protein ID WP_186662972.1
Coordinates 1235160..1235459 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY26_RS05640 (LOY26_05640) 1231021..1231830 + 810 WP_095064085.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
LOY26_RS05645 (LOY26_05645) 1231926..1232336 - 411 WP_186662970.1 SufE family protein -
LOY26_RS05650 (LOY26_05650) 1232333..1233538 - 1206 WP_186654462.1 cysteine desulfurase -
LOY26_RS05655 (LOY26_05655) 1233617..1234651 - 1035 WP_186654464.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
LOY26_RS05660 (LOY26_05660) 1234694..1235041 - 348 WP_077068598.1 ArsC family reductase -
LOY26_RS05665 (LOY26_05665) 1235160..1235459 - 300 WP_186662972.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
LOY26_RS05670 (LOY26_05670) 1235468..1235746 - 279 WP_186654474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY26_RS05675 (LOY26_05675) 1235984..1237630 + 1647 WP_186662974.1 Na+/H+ antiporter -
LOY26_RS05680 (LOY26_05680) 1237668..1238864 - 1197 WP_033700888.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10472.84 Da        Isoelectric Point: 7.1344

>T224980 WP_186654474.1 NZ_CP087169:c1235746-1235468 [Pseudomonas sp. B21-047]
MIRSFSCADTEALFTTGKTQRWSDIKSVVERKLAMLDAAAALRDLRSPPGNRLEPLSGNRDGQHSIRVNDQWRLCFIWTE
NGPVNVEIVDYH

Download         Length: 279 bp

>T224980 NZ_CP087169:c1235746-1235468 [Pseudomonas sp. B21-047]
ATGATTCGAAGCTTCAGTTGTGCTGACACGGAAGCACTCTTTACCACTGGAAAGACGCAGCGATGGTCGGATATCAAGTC
TGTTGTGGAGCGCAAACTCGCCATGCTCGATGCCGCAGCAGCGCTGCGGGACCTTCGCTCGCCACCTGGCAACCGTCTCG
AGCCGTTGAGCGGCAATCGGGACGGCCAGCACAGTATTCGCGTCAATGACCAGTGGCGCTTGTGCTTTATCTGGACCGAA
AACGGTCCGGTTAACGTTGAAATAGTCGATTACCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10921.55 Da        Isoelectric Point: 6.4592

>AT224980 WP_186662972.1 NZ_CP087169:c1235459-1235160 [Pseudomonas sp. B21-047]
MLKNGMRPIHPGEVLREDFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQSTFDLR
TAEQRHGDEIIGSVQRLVA

Download         Length: 300 bp

>AT224980 NZ_CP087169:c1235459-1235160 [Pseudomonas sp. B21-047]
ATGCTCAAGAACGGTATGCGTCCAATACATCCCGGTGAAGTCCTGCGTGAGGACTTTCAGAAAGAAATGGGCTTCAGTGC
TGCCGCGTTGGCAAGGGCGCTGGGCGTCGCCACGCCAACTGTCAACAATATCCTGCGCGAACGGGGCGGCGTGTCTGCCG
ACATGGCGCTGCGTCTTTCCATCTGCCTGGATACCACCCCTGAATTCTGGCTCAACCTGCAGAGTACTTTTGATCTGCGA
ACTGCCGAACAGCGACATGGCGACGAGATCATCGGGTCGGTACAGCGCCTGGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References