Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4870372..4870952 Replicon chromosome
Accession NZ_CP087168
Organism Pseudomonas sp. B21-048

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY56_RS22800 Protein ID WP_258617230.1
Coordinates 4870372..4870650 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY56_RS22805 Protein ID WP_038981447.1
Coordinates 4870665..4870952 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY56_RS22780 (LOY56_22730) 4865948..4866115 - 168 WP_258622847.1 DUF2474 domain-containing protein -
LOY56_RS22785 (LOY56_22735) 4866173..4867180 - 1008 WP_258617227.1 cytochrome d ubiquinol oxidase subunit II -
LOY56_RS22790 (LOY56_22740) 4867184..4868617 - 1434 WP_258617228.1 cytochrome ubiquinol oxidase subunit I -
LOY56_RS22795 (LOY56_22745) 4869002..4870240 + 1239 WP_258617229.1 MFS transporter -
LOY56_RS22800 (LOY56_22750) 4870372..4870650 + 279 WP_258617230.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY56_RS22805 (LOY56_22755) 4870665..4870952 + 288 WP_038981447.1 HigA family addiction module antitoxin Antitoxin
LOY56_RS22810 (LOY56_22760) 4870959..4871510 - 552 WP_258617231.1 DJ-1/PfpI family protein -
LOY56_RS22815 (LOY56_22765) 4871578..4872033 - 456 WP_258617232.1 YolA family protein -
LOY56_RS22820 (LOY56_22770) 4872261..4873556 + 1296 WP_258617233.1 NCS2 family permease -
LOY56_RS22825 (LOY56_22775) 4873553..4874632 + 1080 WP_258617235.1 tRNA (uridine(54)-C5)-methyltransferase TrmA -
LOY56_RS22830 (LOY56_22780) 4874687..4875133 - 447 WP_258617236.1 DUF2442 domain-containing protein -
LOY56_RS22835 (LOY56_22785) 4875130..4875557 - 428 Protein_4483 DUF4160 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-75)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10757.32 Da        Isoelectric Point: 8.5218

>T224976 WP_258617230.1 NZ_CP087168:4870372-4870650 [Pseudomonas sp. B21-048]
MIKSFQHKGLRGFYETGSTRGIRADHAKRLARMLQFMDRAVASDDLDLPGWRLHPLKGDLIEYWSLSVSGNWRVIFRFIG
SDIELVDYLDYH

Download         Length: 279 bp

>T224976 NZ_CP120677:2115005-2115337 [Tissierella sp. Yu-01]
ATGACATATATTCCAGAACAAGGAGATATTATATTTATAGAATTTAATCCTCAGGTCGGGCATGAGCAAAAAGGTAAAAG
ACCGGCCTTAGTTGTAAGTAATTACACATTTAACAAATTCACTAAATTGGCAATGCTATGCCCAATTACCAATACGGATA
GAAGCTTTCCTTTGCATGTTAAACTAGATGAAAGAACGAAAACTACAGGAGTCATCATGTGTGAACAGGTAAAATCCCTA
GATTACAATGCCAGAGCAATATCCTTTTATGAAAGATCACCAGAAGATATAGTAGCAGAAGTTAAAGATGTTTTACTTGG
ATTCATTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10652.33 Da        Isoelectric Point: 6.6041

>AT224976 WP_038981447.1 NZ_CP087168:4870665-4870952 [Pseudomonas sp. B21-048]
MPMHNPPHPGETLLMDVLPELGISVTELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARMWLGVQTDYDLWQA
EQREQPFIEPIAIHA

Download         Length: 288 bp

>AT224976 NZ_CP120677:2114766-2115005 [Tissierella sp. Yu-01]
ATGTTTACTACAATTCAAAAGTGGGGTAATAGTCAAGCCGTTAGAATACCTAAGGCTATTCTAGAAATGGCTAATCTAAG
GGAAAATGACAATGTAGAATTAAGAGTTCATGAAGGCAATCTACTAATTATTCCTGTTAAAAAACATAAATCCCTAGAGC
AACGAATTGCCGAATATGAAGGAGAATACCATTGTAGCGAATGGGAAACTAGTGATCCTATAGGAAAAGAGGTACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References