Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 5089624..5090204 | Replicon | chromosome |
Accession | NZ_CP087167 | ||
Organism | Pseudomonas atacamensis strain B21-050 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A1E8P922 |
Locus tag | LOY49_RS22795 | Protein ID | WP_038861219.1 |
Coordinates | 5089624..5089902 (+) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LOY49_RS22800 | Protein ID | WP_016773085.1 |
Coordinates | 5089917..5090204 (+) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LOY49_RS22775 (LOY49_22745) | 5085116..5085283 | - | 168 | WP_016773090.1 | DUF2474 domain-containing protein | - |
LOY49_RS22780 (LOY49_22750) | 5085361..5086368 | - | 1008 | WP_024014408.1 | cytochrome d ubiquinol oxidase subunit II | - |
LOY49_RS22785 (LOY49_22755) | 5086372..5087817 | - | 1446 | WP_024014409.1 | cytochrome ubiquinol oxidase subunit I | - |
LOY49_RS22790 (LOY49_22760) | 5088288..5089523 | + | 1236 | WP_016773087.1 | MFS transporter | - |
LOY49_RS22795 (LOY49_22765) | 5089624..5089902 | + | 279 | WP_038861219.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
LOY49_RS22800 (LOY49_22770) | 5089917..5090204 | + | 288 | WP_016773085.1 | HigA family addiction module antitoxin | Antitoxin |
LOY49_RS22805 (LOY49_22775) | 5090209..5090760 | - | 552 | WP_016773084.1 | DJ-1/PfpI family protein | - |
LOY49_RS22810 (LOY49_22780) | 5090828..5091274 | - | 447 | WP_206422160.1 | DUF4879 domain-containing protein | - |
LOY49_RS22815 (LOY49_22785) | 5091495..5092790 | + | 1296 | WP_016773083.1 | NCS2 family permease | - |
LOY49_RS22820 (LOY49_22790) | 5092787..5093866 | + | 1080 | WP_258603727.1 | tRNA (uridine(54)-C5)-methyltransferase TrmA | - |
LOY49_RS22825 (LOY49_22795) | 5094061..5094501 | + | 441 | WP_137215639.1 | type II 3-dehydroquinate dehydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10757.32 Da Isoelectric Point: 9.5056
>T224971 WP_038861219.1 NZ_CP087167:5089624-5089902 [Pseudomonas atacamensis]
MIKSFQHKGLRGFYETGTTRGIRADHAKRLSRMLQFMDRATLPGDLDLPGWRLHPLKGELSEYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH
MIKSFQHKGLRGFYETGTTRGIRADHAKRLSRMLQFMDRATLPGDLDLPGWRLHPLKGELSEYWSLSVSGNWRVIFRFVG
SDIELVDYLDYH
Download Length: 279 bp
>T224971 NZ_CP120671:2409136-2409420 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10525.13 Da Isoelectric Point: 6.6962
>AT224971 WP_016773085.1 NZ_CP087167:5089917-5090204 [Pseudomonas atacamensis]
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG
MPMHNPPHPGETLLLDVLPELGISVSELARHLGFARPHLSRVLHGHAPISPDLAVRLERAGIGKARVWLGVQTDYDLWQA
EHREQPMIEPLAAHG
Download Length: 288 bp
>AT224971 NZ_CP120671:2408904-2409146 [Salmonella enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|