Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 284716..285320 Replicon chromosome
Accession NZ_CP087167
Organism Pseudomonas atacamensis strain B21-050

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOY49_RS01215 Protein ID WP_130910162.1
Coordinates 285006..285320 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LOY49_RS01210 Protein ID WP_016772178.1
Coordinates 284716..285003 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY49_RS01190 (LOY49_01190) 280582..280986 + 405 WP_122611135.1 S4 domain-containing protein -
LOY49_RS01195 (LOY49_01195) 281076..281876 - 801 WP_122611134.1 phosphatase PAP2 family protein -
LOY49_RS01200 (LOY49_01200) 281984..282886 + 903 WP_258604472.1 Hsp33 family molecular chaperone HslO -
LOY49_RS01205 (LOY49_01205) 283068..284609 + 1542 WP_016772179.1 phosphoenolpyruvate carboxykinase -
LOY49_RS01210 (LOY49_01210) 284716..285003 - 288 WP_016772178.1 NadS family protein Antitoxin
LOY49_RS01215 (LOY49_01215) 285006..285320 - 315 WP_130910162.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY49_RS01220 (LOY49_01220) 285657..286799 - 1143 WP_258604475.1 hypothetical protein -
LOY49_RS01225 (LOY49_01225) 287073..289007 + 1935 WP_160768534.1 ATP-dependent DNA helicase RecQ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11722.48 Da        Isoelectric Point: 10.2637

>T224963 WP_130910162.1 NZ_CP087167:c285320-285006 [Pseudomonas atacamensis]
MIFIETSVFTRRVRELLDDDAYATFQKQLVANPSIGDVIEGTGGVRKARVASKGHGKRGGARVIYYHFVSASQIALLMIY
PKNEQQDLTHDERKALKAMIGNWR

Download         Length: 315 bp

>T224963 NZ_CP120671:434851-435378 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10753.42 Da        Isoelectric Point: 8.6214

>AT224963 WP_016772178.1 NZ_CP087167:c285003-284716 [Pseudomonas atacamensis]
MSKFFDELMESVQEMDEILRGEKKPSREFYVDALQVKQIRKATGMTQAKFAALIDVQLGTLRNWEQGRRQPTGPAKALLK
AIHNDPVHVLSALAD

Download         Length: 288 bp

>AT224963 NZ_CP120671:434564-434854 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References