Detailed information of TA system TA224954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 4056896..4057596
• Replicon: chromosome
• Accession: NZ_CP087165
• Organism: Pseudomonas sichuanensis strain B21-052

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: LOY46_RS19030
• Protein ID: WP_258704820.1
• Coordinates: 4057300..4057596 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: LOY46_RS19025
• Protein ID: WP_258704819.1
• Coordinates: 4056896..4057297 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY46_RS19005 (LOY46_18985)	4052040..4052861	-	822	WP_258704818.1	transporter substrate-binding domain-containing protein	-
LOY46_RS19010 (LOY46_18990)	4052946..4053875	-	930	WP_125464897.1	FAD-binding protein	-
LOY46_RS19015 (LOY46_18995)	4053876..4054625	-	750	WP_125464898.1	electron transfer flavoprotein subunit beta/FixA family protein	-
LOY46_RS19020 (LOY46_19000)	4055154..4056836	+	1683	WP_125464899.1	electron transfer flavoprotein-ubiquinone oxidoreductase	-
LOY46_RS19025 (LOY46_19005)	4056896..4057297	-	402	WP_258704819.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LOY46_RS19030 (LOY46_19010)	4057300..4057596	-	297	WP_258704820.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LOY46_RS19035 (LOY46_19015)	4057691..4059016	-	1326	WP_258704821.1	MFS transporter	-
LOY46_RS19040 (LOY46_19020)	4059078..4059563	-	486	WP_258704822.1	histidine kinase	-
LOY46_RS19045 (LOY46_19025)	4059732..4060208	-	477	WP_125464904.1	sigma-70 family RNA polymerase sigma factor	-
LOY46_RS19050 (LOY46_19030)	4060427..4061602	+	1176	WP_125859471.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (6-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11195.13 Da
• Isoelectric Point: 8.9903

>T224954 WP_258704820.1 NZ_CP087165:c4057596-4057300 [Pseudomonas sichuanensis]
MEKRVPHCPLDRVKALLAVKRVSPTFAALRGARSLGLDYPGMLDVISSLERTDFYKSMSCYTEHRVWQDVYRPLTAVGYV
YLKLSVVDDVLIVSFKEL

Nucleotide

• Length: 297 bp

>T224954 NZ_CP120639:148139-148540 [Rhizobium sp. 32-5/1]
ATGCTGAAGTACATGCTGGACACCAACATTTGTATTTTCACAATCAAAAATCGACCACAGCAGCTGCGCGAGGCGTTCAA
TCGTTTCCGTGATCAATTGTGCATCAGCTCGGTCAGTTTGATGGAACTGATTTACGGAGCTGAAAAGTCAGCCAGTCCTG
AAAAGAACCTTCCCGTTGTGGAGGGCTTTGCGGCGCGCCTTGAAGTGTTACCGTACGATGAACCGGCAGCAAGCCATACC
GGTCAATTGCGGGCCGAACTGGCGCGCAGTGGAACTCCAATCGGTCCATATGATCAATTGATTGCAGGACATGCTCGCTC
GCGTGGGCTGATTATGGTTACGAACAATCGAAGGGAATTCGATCGCGTTCCCGGCTTACGGGTGGAAGATTGGACGGGTT
AG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14690.69 Da
• Isoelectric Point: 4.9775

>AT224954 WP_258704819.1 NZ_CP087165:c4057297-4056896 [Pseudomonas sichuanensis]
MRCPICGAAELAPDIQDMPYRYKGESTLIQGVSGDYCSACGEAVLSHDEAMRVSEQMTAFERRVNATAVDPAFISAVRKK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALIKLFKLLDRHPELFEEVRTA

Nucleotide

• Length: 402 bp

>AT224954 NZ_CP120639:147909-148139 [Rhizobium sp. 32-5/1]
GTGGAACAGGGTGCAGTATTCCAGAGCAATCGAAGCCAAGCCATCCGTCTTCCCAAGGCAGTCGCTTTGCCTGATGACGT
AAAGCGCGTCGATATTGTAGTCGTTGGACGCACTCGCATTATCGCGCCTGCAGGCGAGGTCTGGGACAGCTGGTTCGAAG
GAGCGGCCGCCACATCCGACTTCATGAGTGAGCGTGATCAGACCGCCTCCCAGGAGCGCGAGGCATTTTAA