Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 132018..132271 Replicon plasmid unnamed2
Accession NZ_CP087144
Organism Klebsiella pneumoniae strain KP15

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag LOX91_RS29000 Protein ID WP_001312851.1
Coordinates 132122..132271 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 132018..132077 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX91_RS28960 (127400) 127400..127744 - 345 Protein_161 IS6-like element IS26 family transposase -
LOX91_RS28965 (127796) 127796..128500 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
LOX91_RS28970 (128525) 128525..128725 + 201 WP_072354025.1 hypothetical protein -
LOX91_RS28975 (128745) 128745..129491 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
LOX91_RS28980 (129546) 129546..130106 + 561 WP_000139328.1 fertility inhibition protein FinO -
LOX91_RS28985 (130238) 130238..130438 + 201 WP_015059022.1 hypothetical protein -
LOX91_RS28990 (130824) 130824..131423 + 600 WP_032083981.1 PIN domain-containing protein -
LOX91_RS28995 (131485) 131485..131817 + 333 WP_152916585.1 hypothetical protein -
- (132018) 132018..132077 - 60 NuclAT_1 - Antitoxin
- (132018) 132018..132077 - 60 NuclAT_1 - Antitoxin
- (132018) 132018..132077 - 60 NuclAT_1 - Antitoxin
- (132018) 132018..132077 - 60 NuclAT_1 - Antitoxin
LOX91_RS29000 (132122) 132122..132271 + 150 WP_001312851.1 Hok/Gef family protein Toxin
LOX91_RS29005 (132555) 132555..132803 + 249 WP_000083837.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 - 1..133114 133114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T224887 WP_001312851.1 NZ_CP087144:132122-132271 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T224887 NZ_CP120569:c63578-63429 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 60 bp

>AT224887 NZ_CP087144:c132077-132018 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References