224884

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 34998..35267 Replicon plasmid unnamed2
Accession NZ_CP087144
Organism Klebsiella pneumoniae strain KP15

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag LOX91_RS28390 Protein ID WP_001372321.1
Coordinates 35142..35267 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 34998..35063 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX91_RS28360 30708..31235 + 528 WP_000290834.1 single-stranded DNA-binding protein -
LOX91_RS28365 31293..31526 + 234 WP_000006003.1 DUF905 family protein -
LOX91_RS28370 31587..33610 + 2024 Protein_43 ParB/RepB/Spo0J family partition protein -
LOX91_RS28375 33679..34113 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
LOX91_RS28380 34110..34829 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 34841..35065 + 225 NuclAT_0 - -
- 34841..35065 + 225 NuclAT_0 - -
- 34841..35065 + 225 NuclAT_0 - -
- 34841..35065 + 225 NuclAT_0 - -
- 34998..35063 - 66 - - Antitoxin
LOX91_RS28385 35051..35200 + 150 Protein_46 plasmid maintenance protein Mok -
LOX91_RS28390 35142..35267 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
LOX91_RS28395 35586..35882 - 297 Protein_48 hypothetical protein -
LOX91_RS28400 36182..36478 + 297 WP_001272251.1 hypothetical protein -
LOX91_RS28405 36589..37410 + 822 WP_001234445.1 DUF932 domain-containing protein -
LOX91_RS28410 37707..38354 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
LOX91_RS28415 38631..39014 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
LOX91_RS28420 39295..39999 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 - 1..133114 133114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T224884 WP_001372321.1 NZ_CP087144:35142-35267 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp

>T224884 NZ_CP120568:3871184-3871462 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 66 bp

>AT224884 NZ_CP087144:c35063-34998 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References