Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 34998..35267 | Replicon | plasmid unnamed2 |
Accession | NZ_CP087144 | ||
Organism | Klebsiella pneumoniae strain KP15 |
Toxin (Protein)
Gene name | hok | Uniprot ID | - |
Locus tag | LOX91_RS28390 | Protein ID | WP_001372321.1 |
Coordinates | 35142..35267 (+) | Length | 42 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 34998..35063 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LOX91_RS28360 | 30708..31235 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
LOX91_RS28365 | 31293..31526 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
LOX91_RS28370 | 31587..33610 | + | 2024 | Protein_43 | ParB/RepB/Spo0J family partition protein | - |
LOX91_RS28375 | 33679..34113 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
LOX91_RS28380 | 34110..34829 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- | 34841..35065 | + | 225 | NuclAT_0 | - | - |
- | 34841..35065 | + | 225 | NuclAT_0 | - | - |
- | 34841..35065 | + | 225 | NuclAT_0 | - | - |
- | 34841..35065 | + | 225 | NuclAT_0 | - | - |
- | 34998..35063 | - | 66 | - | - | Antitoxin |
LOX91_RS28385 | 35051..35200 | + | 150 | Protein_46 | plasmid maintenance protein Mok | - |
LOX91_RS28390 | 35142..35267 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
LOX91_RS28395 | 35586..35882 | - | 297 | Protein_48 | hypothetical protein | - |
LOX91_RS28400 | 36182..36478 | + | 297 | WP_001272251.1 | hypothetical protein | - |
LOX91_RS28405 | 36589..37410 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
LOX91_RS28410 | 37707..38354 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
LOX91_RS28415 | 38631..39014 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
LOX91_RS28420 | 39295..39999 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 | - | 1..133114 | 133114 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T224884 WP_001372321.1 NZ_CP087144:35142-35267 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T224884 NZ_CP120568:3871184-3871462 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 66 bp
>AT224884 NZ_CP087144:c35063-34998 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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