Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3692510..3692732 Replicon chromosome
Accession NZ_CP087136
Organism Escherichia coli strain JW5503

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag LOX89_RS18050 Protein ID WP_000141634.1
Coordinates 3692510..3692617 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3692666..3692732 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX89_RS18025 3687763..3688491 - 729 WP_011310329.1 cellulose biosynthesis protein BcsQ -
LOX89_RS18030 3688527..3688715 - 189 WP_001063318.1 cellulose biosynthesis protein BcsR -
LOX89_RS18035 3688988..3690559 + 1572 WP_001204931.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
LOX89_RS18040 3690556..3690747 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
LOX89_RS18045 3690744..3692423 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
LOX89_RS18050 3692510..3692617 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3692666..3692732 + 67 - - Antitoxin
LOX89_RS18055 3693093..3694364 + 1272 WP_001295225.1 aromatic amino acid transport family protein -
LOX89_RS18060 3694394..3695398 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
LOX89_RS18065 3695395..3696378 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
LOX89_RS18070 3696389..3697291 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T224849 WP_000141634.1 NZ_CP087136:c3692617-3692510 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T224849 NZ_CP120567:185223-185330 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT224849 NZ_CP087136:3692666-3692732 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References