Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3161757..3162450 Replicon chromosome
Accession NZ_CP087136
Organism Escherichia coli strain JW5503

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LOX89_RS15450 Protein ID WP_000415584.1
Coordinates 3162154..3162450 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LOX89_RS15445 Protein ID WP_000650107.1
Coordinates 3161757..3162152 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX89_RS15435 (3157621) 3157621..3159879 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
LOX89_RS15440 (3160017) 3160017..3161624 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LOX89_RS15445 (3161757) 3161757..3162152 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LOX89_RS15450 (3162154) 3162154..3162450 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LOX89_RS15455 (3162655) 3162655..3163137 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LOX89_RS15460 (3163190) 3163190..3163582 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LOX89_RS15465 (3163734) 3163734..3164393 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LOX89_RS15470 (3164390) 3164390..3165739 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LOX89_RS15475 (3165785) 3165785..3166117 - 333 WP_000917684.1 DUF2645 family protein -
LOX89_RS15480 (3166436) 3166436..3167017 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LOX89_RS15485 (3167048) 3167048..3167362 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T224846 WP_000415584.1 NZ_CP087136:c3162450-3162154 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T224846 NZ_CP120564:c55810-55535 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
CGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTCGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT224846 WP_000650107.1 NZ_CP087136:c3162152-3161757 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT224846 NZ_CP120564:c56094-55810 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAACCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References