Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1408360..1408731 | Replicon | chromosome |
| Accession | NZ_CP087136 | ||
| Organism | Escherichia coli strain JW5503 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | F4VC37 |
| Locus tag | LOX89_RS06985 | Protein ID | WP_001317028.1 |
| Coordinates | 1408537..1408731 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1408360..1408538 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOX89_RS22545 (1404112) | 1404112..1404285 | + | 174 | WP_001296046.1 | protein YnaL | - |
| LOX89_RS06960 (1404315) | 1404315..1405688 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
| LOX89_RS06965 (1405817) | 1405817..1406752 | - | 936 | WP_001157406.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| LOX89_RS06970 (1406804) | 1406804..1408039 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
| LOX89_RS06975 (1408041) | 1408041..1408256 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1408360) | 1408360..1408538 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1408360) | 1408360..1408538 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1408360) | 1408360..1408538 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1408360) | 1408360..1408538 | + | 179 | NuclAT_0 | - | Antitoxin |
| LOX89_RS06980 (1408335) | 1408335..1408544 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
| LOX89_RS06985 (1408537) | 1408537..1408731 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| LOX89_RS06990 (1408788) | 1408788..1409597 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
| LOX89_RS06995 (1409590) | 1409590..1412190 | - | 2601 | WP_000105143.1 | exodeoxyribonuclease VIII | - |
| LOX89_RS07000 (1412292) | 1412292..1412567 | - | 276 | WP_000632297.1 | protein RacC | - |
| LOX89_RS07005 (1412642) | 1412642..1412812 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| LOX89_RS07010 (1412812) | 1412812..1413033 | - | 222 | WP_000560225.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1341782..1428478 | 86696 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T224825 WP_001317028.1 NZ_CP087136:c1408731-1408537 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T224825 NZ_CP120559:64032-64184 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 179 bp
>AT224825 NZ_CP087136:1408360-1408538 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
