Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 3126611..3127844 | Replicon | chromosome |
| Accession | NZ_CP087132 | ||
| Organism | Flavobacterium sp. F-29 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | - |
| Locus tag | LNP19_RS13540 | Protein ID | WP_230062428.1 |
| Coordinates | 3126611..3127537 (-) | Length | 309 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | - |
| Locus tag | LNP19_RS13545 | Protein ID | WP_230062429.1 |
| Coordinates | 3127530..3127844 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNP19_RS13525 (LNP19_13525) | 3123715..3123969 | - | 255 | WP_230062425.1 | hypothetical protein | - |
| LNP19_RS13530 (LNP19_13530) | 3124008..3125807 | + | 1800 | WP_230062426.1 | hypothetical protein | - |
| LNP19_RS13535 (LNP19_13535) | 3125979..3126437 | - | 459 | WP_230062427.1 | RNA methyltransferase | - |
| LNP19_RS13540 (LNP19_13540) | 3126611..3127537 | - | 927 | WP_230062428.1 | HipA domain-containing protein | Toxin |
| LNP19_RS13545 (LNP19_13545) | 3127530..3127844 | - | 315 | WP_230062429.1 | HipA N-terminal domain-containing protein | Antitoxin |
| LNP19_RS13550 (LNP19_13550) | 3127847..3128056 | - | 210 | WP_230062430.1 | helix-turn-helix domain-containing protein | - |
| LNP19_RS13555 (LNP19_13555) | 3128288..3128785 | + | 498 | WP_230062431.1 | helix-turn-helix domain-containing protein | - |
| LNP19_RS13560 (LNP19_13560) | 3128785..3129432 | + | 648 | WP_230062432.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LNP19_RS13565 (LNP19_13565) | 3129454..3129570 | + | 117 | WP_255666013.1 | type II toxin-antitoxin system HigB family toxin | - |
| LNP19_RS13570 (LNP19_13570) | 3129615..3129971 | + | 357 | WP_230062433.1 | helix-turn-helix domain-containing protein | - |
| LNP19_RS13575 (LNP19_13575) | 3130683..3131300 | + | 618 | WP_230062434.1 | GNAT family N-acetyltransferase | - |
| LNP19_RS13580 (LNP19_13580) | 3131384..3132577 | + | 1194 | WP_230062435.1 | argininosuccinate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3065514..3146817 | 81303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 309 a.a. Molecular weight: 35456.16 Da Isoelectric Point: 8.3946
>T224814 WP_230062428.1 NZ_CP087132:c3127537-3126611 [Flavobacterium sp. F-29]
MNRCPITYELCGTDKYSEKGLRLIAPKLTFLKDLPYTAVELRQEAANRAKKLSIQGVQPKLSAAISIVDQEFKIVDQFGT
YIIKPQNDLFPQLPENEDLTMRMAKVFGLEVPFHGMLYAKDGSLSYFIKRFDRYGKGKKLATEDFAQLTANTRDTKYRFT
MEKLIPVLDEFCSFPAIEKADFFKRILFCYVTGNEDMHLKNFSLITKNGKTTLTSVYDFLNSTIAVKNPEEEIALTLKGK
KSNLKAADFVDYYAKERLELNEKTIANILQQMQEAIPKWKELLEISFLSGDMKEKYLELLESRVGMFQ
MNRCPITYELCGTDKYSEKGLRLIAPKLTFLKDLPYTAVELRQEAANRAKKLSIQGVQPKLSAAISIVDQEFKIVDQFGT
YIIKPQNDLFPQLPENEDLTMRMAKVFGLEVPFHGMLYAKDGSLSYFIKRFDRYGKGKKLATEDFAQLTANTRDTKYRFT
MEKLIPVLDEFCSFPAIEKADFFKRILFCYVTGNEDMHLKNFSLITKNGKTTLTSVYDFLNSTIAVKNPEEEIALTLKGK
KSNLKAADFVDYYAKERLELNEKTIANILQQMQEAIPKWKELLEISFLSGDMKEKYLELLESRVGMFQ
Download Length: 927 bp
>T224814 NZ_CP120557:c2643274-2642960 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11720.40 Da Isoelectric Point: 4.8616
>AT224814 WP_230062429.1 NZ_CP087132:c3127844-3127530 [Flavobacterium sp. F-29]
MRKAIVLVHGKRAGILTETTSNDYHFEYDENYEGDAVSLTMPVSHKKYSYTSFPPFFEGVLPEGVMLEGLLRIVKIDKKD
YFSQLIATGNDLVGAVTVKLMEDE
MRKAIVLVHGKRAGILTETTSNDYHFEYDENYEGDAVSLTMPVSHKKYSYTSFPPFFEGVLPEGVMLEGLLRIVKIDKKD
YFSQLIATGNDLVGAVTVKLMEDE
Download Length: 315 bp
>AT224814 NZ_CP120557:c2642963-2642547 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGCTCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|