Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 776920..777361 Replicon chromosome
Accession NZ_CP087124
Organism Sulfurovum sp. HSL1-3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LN246_RS15205 Protein ID WP_256444111.1
Coordinates 776920..777054 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LN246_RS03940 Protein ID WP_229937854.1
Coordinates 777047..777361 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN246_RS03930 (LN246_03930) 773466..774875 - 1410 WP_229937852.1 cysteine--tRNA ligase -
LN246_RS03935 (LN246_03935) 774925..776331 - 1407 WP_229937853.1 murein biosynthesis integral membrane protein MurJ -
LN246_RS15205 776920..777054 + 135 WP_256444111.1 hypothetical protein Toxin
LN246_RS03940 (LN246_03940) 777047..777361 + 315 WP_229937854.1 transcriptional regulator Antitoxin
LN246_RS03945 (LN246_03945) 777545..778240 + 696 WP_229937855.1 CRISPR-associated endoribonuclease Cas6 -
LN246_RS03950 (LN246_03950) 778237..779694 + 1458 WP_229937856.1 hypothetical protein -
LN246_RS03955 (LN246_03955) 779697..780212 + 516 WP_229937857.1 hypothetical protein -
LN246_RS03960 (LN246_03960) 780209..781282 + 1074 WP_229937858.1 type I-B CRISPR-associated protein Cas7/Csh2 -
LN246_RS03965 (LN246_03965) 781275..782039 + 765 WP_229937859.1 CRISPR-associated protein Cas5 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(43-89)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 5091.01 Da        Isoelectric Point: 8.5158

>T224811 WP_256444111.1 NZ_CP087124:776920-777054 [Sulfurovum sp. HSL1-3]
MIYLYLTDKSHIHLLTIYAKNEMEALTPSQKKVLKAITEEIKNG

Download         Length: 135 bp

>T224811 NZ_CP120557:c2359239-2358832 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTAGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12190.05 Da        Isoelectric Point: 8.4723

>AT224811 WP_229937854.1 NZ_CP087124:777047-777361 [Sulfurovum sp. HSL1-3]
MGKRDLFAELKQGLDDARAYEEAKLTLRTTEVTPKERKVLTPEEIRGIREKYRMSRAVFANFLHISTRTLEKWELGTSKP
NEQAVTLLALTDMYPDMFERLERV

Download         Length: 315 bp

>AT224811 NZ_CP120557:c2359486-2359220 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References