Detailed information of TA system TA224789

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 5520930..5521199
• Replicon: chromosome
• Accession: NZ_CP087122
• Organism: Klebsiella pneumoniae strain TH12852

Toxin (Protein)

• Gene name: hok
• Uniprot ID: G9G195
• Locus tag: LOX64_RS26980
• Protein ID: WP_001323520.1
• Coordinates: 5521083..5521199 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	5520930..5520995 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOX64_RS26950	5516640..5517167	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
LOX64_RS26955	5517225..5517458	+	234	WP_000006003.1	DUF905 family protein	-
LOX64_RS26960	5517519..5519542	+	2024	Protein_5265	ParB/RepB/Spo0J family partition protein	-
LOX64_RS26965	5519611..5520045	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
LOX64_RS26970	5520042..5520761	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	5520773..5520997	+	225	NuclAT_0	-	-
-	5520773..5520997	+	225	NuclAT_0	-	-
-	5520773..5520997	+	225	NuclAT_0	-	-
-	5520773..5520997	+	225	NuclAT_0	-	-
-	5520930..5520995	-	66	-	-	Antitoxin
LOX64_RS26975	5520983..5521132	+	150	Protein_5268	plasmid maintenance protein Mok	-
LOX64_RS26980	5521083..5521199	+	117	WP_001323520.1	type I toxin-antitoxin system Hok family toxin	Toxin
LOX64_RS26985	5521518..5521814	-	297	Protein_5270	hypothetical protein	-
LOX64_RS26990	5522114..5522410	+	297	WP_001272251.1	hypothetical protein	-
LOX64_RS26995	5522521..5523342	+	822	WP_001234445.1	DUF932 domain-containing protein	-
LOX64_RS27000	5523639..5524286	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
LOX64_RS27005	5524563..5524946	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
LOX64_RS27010	5525137..5525823	+	687	WP_015059009.1	PAS domain-containing protein	-
LOX64_RS27015	5525917..5526144	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-34)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4455.23 Da
• Isoelectric Point: 8.5110

>T224789 WP_001323520.1 NZ_CP087122:5521083-5521199 [Klebsiella pneumoniae]
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 117 bp

>T224789 NZ_CP120549:c4141110-4140796 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT224789 NZ_CP087122:c5520995-5520930 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Toxin

• AlphaFold DB: G9G195

Antitoxin