Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 349272..349918 Replicon chromosome
Accession NZ_CP087122
Organism Klebsiella pneumoniae strain TH12852

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LOX64_RS01615 Protein ID WP_229982445.1
Coordinates 349272..349619 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LOX64_RS01620 Protein ID WP_002920557.1
Coordinates 349619..349918 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX64_RS01605 (345198) 345198..346631 + 1434 WP_002920564.1 glycogen synthase GlgA -
LOX64_RS01610 (346649) 346649..349096 + 2448 WP_002920561.1 glycogen phosphorylase -
LOX64_RS01615 (349272) 349272..349619 + 348 WP_229982445.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOX64_RS01620 (349619) 349619..349918 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LOX64_RS01625 (349981) 349981..351489 - 1509 WP_038432529.1 glycerol-3-phosphate dehydrogenase -
LOX64_RS01630 (351694) 351694..352023 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LOX64_RS01635 (352074) 352074..352904 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LOX64_RS01640 (352954) 352954..353712 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(9-87)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13522.49 Da        Isoelectric Point: 6.2327

>T224767 WP_229982445.1 NZ_CP087122:349272-349619 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEYAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T224767 NZ_CP120522:c61662-61177 [Enterobacter roggenkampii]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATAGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT224767 WP_002920557.1 NZ_CP087122:349619-349918 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT224767 NZ_CP120522:c61916-61650 [Enterobacter roggenkampii]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References