Detailed information of TA system TA224759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1150000..1150627
• Replicon: chromosome
• Accession: NZ_CP087114
• Organism: Bartonella machadoae strain 46A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LNM86_RS05415
• Protein ID: WP_241438745.1
• Coordinates: 1150000..1150314 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LNM86_RS05420
• Protein ID: WP_241438746.1
• Coordinates: 1150331..1150627 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNM86_RS05390 (LNM86_05390)	1146461..1147567	-	1107	WP_241438741.1	phage tail protein	-
LNM86_RS05395 (LNM86_05395)	1147567..1148394	-	828	WP_241438011.1	baseplate J/gp47 family protein	-
LNM86_RS05400 (LNM86_05400)	1148391..1148732	-	342	WP_241438012.1	GPW/gp25 family protein	-
LNM86_RS05405 (LNM86_05405)	1148729..1149418	-	690	WP_241438926.1	phage baseplate assembly protein V	-
LNM86_RS05410 (LNM86_05410)	1149411..1149947	-	537	WP_241438743.1	hypothetical protein	-
LNM86_RS05415 (LNM86_05415)	1150000..1150314	+	315	WP_241438745.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LNM86_RS05420 (LNM86_05420)	1150331..1150627	+	297	WP_241438746.1	HigA family addiction module antitoxin	Antitoxin
LNM86_RS05425 (LNM86_05425)	1150668..1150946	-	279	WP_241438747.1	hypothetical protein	-
LNM86_RS05430 (LNM86_05430)	1150943..1151674	-	732	WP_241438748.1	antA/AntB antirepressor family protein	-
LNM86_RS05435 (LNM86_05435)	1151992..1152342	-	351	WP_241438749.1	hypothetical protein	-
LNM86_RS05440 (LNM86_05440)	1152344..1153420	-	1077	WP_241438020.1	major capsid protein	-
LNM86_RS05445 (LNM86_05445)	1153433..1153801	-	369	WP_241438183.1	head decoration protein	-
LNM86_RS05450 (LNM86_05450)	1153798..1154178	-	381	WP_241438927.1	hypothetical protein	-
LNM86_RS05455 (LNM86_05455)	1154061..1155128	-	1068	WP_241438750.1	S49 family peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1089827..1184271	94444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12207.15 Da
• Isoelectric Point: 9.8708

>T224759 WP_241438745.1 NZ_CP087114:1150000-1150314 [Bartonella machadoae]
MIHKRMNKGDLVIESFADKRCKDLLEGNPPRGFPTTLVRIAQRKLFMLDKAVDLKDLRSPPGNRLELLKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T224759 NZ_CP120426:c23280-23071 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATAAATGTTTCAGGTATTAAAACAACTGAACAAGCTAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCTGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTACGGATTTCGTATTTTGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11367.02 Da
• Isoelectric Point: 5.8690

>AT224759 WP_241438746.1 NZ_CP087114:1150331-1150627 [Bartonella machadoae]
MRNYSAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIIAEKSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFSKINKFECRV

Nucleotide

• Length: 297 bp

>AT224759 NZ_CP120426:c23580-23287 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATAAATCGTATGATTGATGATGACGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTACTAAATTACTAGACCATCACATGAAAGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA