Detailed information of TA system TA022472

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 348442..348974
• Replicon: chromosome
• Accession: NC_009802
• Organism: Campylobacter concisus 13826

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: CCC13826_RS01765
• Protein ID: WP_196768710.1
• Coordinates: 348442..348693 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: CCC13826_RS01770
• Protein ID: WP_012001250.1
• Coordinates: 348690..348974 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCC13826_RS01755	344530..346671	+	2142	WP_048809750.1	tyrosine-type recombinase/integrase	-
CCC13826_RS01760	346809..348008	+	1200	WP_012001248.1	AAA family ATPase	-
CCC13826_RS01765	348442..348693	+	252	WP_196768710.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CCC13826_RS01770	348690..348974	+	285	WP_012001250.1	helix-turn-helix domain-containing protein	Antitoxin
CCC13826_RS01775	349168..351186	-	2019	WP_012001251.1	AAA family ATPase	-
CCC13826_RS01780	351318..352598	-	1281	WP_012001252.1	DUF2130 domain-containing protein	-
CCC13826_RS01785	352641..353537	-	897	WP_012001253.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (3-80)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9329.14 Da
• Isoelectric Point: 11.1775

>T22472 WP_196768710.1 NC_009802:348442-348693 [Campylobacter concisus 13826]
MANLLRILEMAREVGPNLGRPHSAPLGDGLFEFRAKGKEGIARSVFVNVVNREIVILHTLIKKSDAIPKKDMRIIIQRAK
EIK

Nucleotide

• Length: 252 bp

>T22472 NC_009802:348442-348693 [Campylobacter concisus 13826]
TTGGCTAATTTACTTCGCATACTTGAAATGGCTAGGGAGGTTGGACCAAATTTAGGCAGACCTCATAGCGCACCTCTTGG
CGATGGACTATTTGAGTTTAGGGCAAAAGGCAAAGAAGGTATTGCAAGAAGTGTCTTTGTAAATGTCGTAAATAGAGAAA
TAGTGATTTTACATACGCTCATTAAAAAATCAGACGCTATCCCTAAAAAAGATATGAGGATCATCATACAAAGAGCAAAG
GAGATAAAATGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10840.45 Da
• Isoelectric Point: 9.7977

>AT22472 WP_012001250.1 NC_009802:348690-348974 [Campylobacter concisus 13826]
MRPTFEDFKVKALEKEEVKKEYDRLEVEFDLKLKLIKIRKAANLTQEEIASRMNTSKSNISRLESLNSKISPTISTLNAY
ANAAGYRLDVNFVQ

Nucleotide

• Length: 285 bp

>AT22472 NC_009802:348690-348974 [Campylobacter concisus 13826]
ATGAGACCAACATTTGAAGATTTTAAAGTAAAAGCACTAGAAAAAGAGGAAGTAAAAAAAGAATACGATAGACTTGAAGT
TGAATTTGATTTAAAGTTAAAGCTTATAAAGATCAGAAAAGCCGCAAATCTAACTCAAGAGGAGATAGCTAGTAGAATGA
ATACTAGTAAAAGCAACATCTCAAGACTAGAGAGCCTAAACTCTAAAATTTCACCAACAATCTCTACTTTAAATGCCTAT
GCTAATGCTGCGGGATATAGGCTTGACGTTAATTTTGTGCAATAG