Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 176449..176963 Replicon plasmid P4
Accession NZ_CP087077
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-14

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE32_RS22395 Protein ID WP_224556955.1
Coordinates 176449..176715 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE32_RS22400 Protein ID WP_224556953.1
Coordinates 176712..176963 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE32_RS22380 (LOE32_22370) 173677..174558 + 882 WP_224556958.1 zinc-binding dehydrogenase -
LOE32_RS22385 (LOE32_22375) 174776..175479 - 704 Protein_172 IS6 family transposase -
LOE32_RS22390 (LOE32_22380) 175570..176388 + 819 WP_229940646.1 hypothetical protein -
LOE32_RS22395 (LOE32_22385) 176449..176715 - 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE32_RS22400 (LOE32_22390) 176712..176963 - 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE32_RS22405 (LOE32_22395) 177595..178506 - 912 Protein_176 IS3 family transposase -
LOE32_RS22410 (LOE32_22400) 178507..179451 - 945 Protein_177 transposase -
LOE32_RS22415 (LOE32_22405) 179617..180108 + 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE32_RS22420 (LOE32_22410) 180350..180706 + 357 WP_224556951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fcl / gmd 1..281178 281178
- flank IS/Tn - - 177595..178422 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224701 WP_224556955.1 NZ_CP087077:c176715-176449 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224701 NZ_CP120396:c1368007-1367789 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224701 WP_224556953.1 NZ_CP087077:c176963-176712 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224701 NZ_CP120396:c1368409-1368035 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References