Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 227751..228265 Replicon plasmid P4
Accession NZ_CP087063
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-24

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE35_RS22645 Protein ID WP_224556955.1
Coordinates 227999..228265 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE35_RS22640 Protein ID WP_224556953.1
Coordinates 227751..228002 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE35_RS22620 (LOE35_22635) 224008..224364 - 357 WP_224556951.1 hypothetical protein -
LOE35_RS22625 (LOE35_22640) 224606..225031 - 426 WP_229939140.1 3-keto-5-aminohexanoate cleavage protein -
LOE35_RS22630 (LOE35_22645) 225263..226207 + 945 Protein_217 transposase -
LOE35_RS22635 (LOE35_22650) 226208..227119 + 912 Protein_218 IS3 family transposase -
LOE35_RS22640 (LOE35_22655) 227751..228002 + 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE35_RS22645 (LOE35_22660) 227999..228265 + 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE35_RS22650 (LOE35_22665) 228326..229144 - 819 WP_229940646.1 hypothetical protein -
LOE35_RS22655 (LOE35_22670) 229235..229938 + 704 Protein_222 IS6 family transposase -
LOE35_RS22660 (LOE35_22675) 230156..231037 - 882 WP_224556958.1 zinc-binding dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / fcl 1..281174 281174
- flank IS/Tn - - 226292..227119 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224687 WP_224556955.1 NZ_CP087063:227999-228265 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224687 NZ_CP120395:c1404432-1404214 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224687 WP_224556953.1 NZ_CP087063:227751-228002 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224687 NZ_CP120395:c1404834-1404460 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References