Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 255052..255566 Replicon plasmid P5
Accession NZ_CP087056
Organism Pseudosulfitobacter pseudonitzschiae strain MC36-43

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE36_RS23370 Protein ID WP_224556955.1
Coordinates 255300..255566 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE36_RS23365 Protein ID WP_224556953.1
Coordinates 255052..255303 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE36_RS23345 (LOE36_23380) 251309..251665 - 357 WP_224556951.1 hypothetical protein -
LOE36_RS23350 (LOE36_23385) 251907..252398 - 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE36_RS23355 (LOE36_23390) 252564..253508 + 945 Protein_246 transposase -
LOE36_RS23360 (LOE36_23395) 253509..254420 + 912 Protein_247 IS3 family transposase -
LOE36_RS23365 (LOE36_23400) 255052..255303 + 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE36_RS23370 (LOE36_23405) 255300..255566 + 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE36_RS23375 (LOE36_23410) 255627..256445 - 819 WP_229940646.1 hypothetical protein -
LOE36_RS23380 (LOE36_23415) 256536..257239 + 704 Protein_251 IS6 family transposase -
LOE36_RS23385 (LOE36_23420) 257457..258338 - 882 WP_224556958.1 zinc-binding dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / fcl 1..281173 281173
- flank IS/Tn - - 253593..254420 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224682 WP_224556955.1 NZ_CP087056:255300-255566 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224682 NZ_CP120394:4637996-4638307 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224682 WP_224556953.1 NZ_CP087056:255052-255303 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224682 NZ_CP120394:4638304-4638750 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References