Detailed information of TA system TA224651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 179439..179953
• Replicon: plasmid P4
• Accession: NZ_CP087013
• Organism: Pseudosulfitobacter pseudonitzschiae strain MC52-71

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LOE46_RS22440
• Protein ID: WP_224556955.1
• Coordinates: 179687..179953 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LOE46_RS22435
• Protein ID: WP_229943298.1
• Coordinates: 179439..179690 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOE46_RS22415 (LOE46_22420)	175696..176052	-	357	WP_224556951.1	hypothetical protein	-
LOE46_RS22420 (LOE46_22425)	176294..176719	-	426	WP_229939140.1	3-keto-5-aminohexanoate cleavage protein	-
LOE46_RS22425 (LOE46_22430)	176951..177895	+	945	Protein_173	transposase	-
LOE46_RS22430 (LOE46_22435)	177896..178807	+	912	Protein_174	IS3 family transposase	-
LOE46_RS22435 (LOE46_22440)	179439..179690	+	252	WP_229943298.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LOE46_RS22440 (LOE46_22445)	179687..179953	+	267	WP_224556955.1	Txe/YoeB family addiction module toxin	Toxin
LOE46_RS22445 (LOE46_22450)	180014..180832	-	819	WP_229940646.1	hypothetical protein	-
LOE46_RS22450 (LOE46_22455)	180923..181626	+	704	Protein_178	IS6 family transposase	-
LOE46_RS22455 (LOE46_22460)	181844..182725	-	882	WP_224556958.1	zinc-binding dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	gmd / fcl	1..281175	281175
	-	flank	IS/Tn	-	-	177980..178807	827

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.78 Da
• Isoelectric Point: 9.5014

>T224651 WP_224556955.1 NZ_CP087013:179687-179953 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Nucleotide

• Length: 267 bp

>T224651 NZ_CP120392:1958708-1958810 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9151.40 Da
• Isoelectric Point: 6.4641

>AT224651 WP_229943298.1 NZ_CP087013:179439-179690 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLDTWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Nucleotide

• Length: 252 bp

>AT224651 NZ_CP120392:c1958812-1958669 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG