Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 165614..166128 Replicon plasmid P1
Accession NZ_CP086855
Organism Pseudosulfitobacter pseudonitzschiae strain SC33-25

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE30_RS19915 Protein ID WP_224556955.1
Coordinates 165614..165880 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE30_RS19920 Protein ID WP_224556953.1
Coordinates 165877..166128 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE30_RS19900 (LOE30_19895) 162842..163723 + 882 WP_224556958.1 zinc-binding dehydrogenase -
LOE30_RS19905 (LOE30_19900) 163941..164644 - 704 Protein_155 IS6 family transposase -
LOE30_RS19910 (LOE30_19905) 165086..165553 + 468 WP_224556957.1 hypothetical protein -
LOE30_RS19915 (LOE30_19910) 165614..165880 - 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE30_RS19920 (LOE30_19915) 165877..166128 - 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE30_RS19925 (LOE30_19920) 166760..167671 - 912 Protein_159 IS3 family transposase -
LOE30_RS19930 (LOE30_19925) 167672..168616 - 945 Protein_160 transposase -
LOE30_RS19935 (LOE30_19930) 168782..169273 + 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE30_RS19940 (LOE30_19935) 169515..169871 + 357 WP_224556951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fcl / gmd 1..281179 281179
- flank IS/Tn - - 166760..167587 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224524 WP_224556955.1 NZ_CP086855:c165880-165614 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224524 NZ_CP120341:836072-836470 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTTGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224524 WP_224556953.1 NZ_CP086855:c166128-165877 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224524 NZ_CP120341:835845-836072 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References