Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 230888..231402 Replicon plasmid P5
Accession NZ_CP086829
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-5

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE28_RS23625 Protein ID WP_224556955.1
Coordinates 231136..231402 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE28_RS23620 Protein ID WP_224556953.1
Coordinates 230888..231139 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE28_RS23600 (LOE28_23605) 227145..227501 - 357 WP_224556951.1 hypothetical protein -
LOE28_RS23605 (LOE28_23610) 227743..228234 - 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE28_RS23610 (LOE28_23615) 228400..229344 + 945 Protein_222 transposase -
LOE28_RS23615 (LOE28_23620) 229345..230256 + 912 Protein_223 IS3 family transposase -
LOE28_RS23620 (LOE28_23625) 230888..231139 + 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE28_RS23625 (LOE28_23630) 231136..231402 + 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE28_RS23630 (LOE28_23635) 231463..232281 - 819 WP_229940646.1 hypothetical protein -
LOE28_RS23635 (LOE28_23640) 232372..233075 + 704 Protein_227 IS6 family transposase -
LOE28_RS23640 (LOE28_23645) 233293..234174 - 882 WP_224556958.1 zinc-binding dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - gmd / fcl 1..281172 281172
- flank IS/Tn - - 229429..230256 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224502 WP_224556955.1 NZ_CP086829:231136-231402 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224502 NZ_CP120337:c4216823-4216539 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224502 WP_224556953.1 NZ_CP086829:230888-231139 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224502 NZ_CP120337:c4217055-4216813 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References