Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 155598..156112 Replicon plasmid P1
Accession NZ_CP086809
Organism Pseudosulfitobacter pseudonitzschiae strain TC12-54

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE27_RS19720 Protein ID WP_224556955.1
Coordinates 155598..155864 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE27_RS19725 Protein ID WP_224556953.1
Coordinates 155861..156112 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE27_RS19705 (LOE27_19690) 152826..153707 + 882 WP_224556958.1 zinc-binding dehydrogenase -
LOE27_RS19710 (LOE27_19695) 153925..154628 - 704 Protein_145 IS6 family transposase -
LOE27_RS19715 (LOE27_19700) 154719..155537 + 819 WP_229940646.1 hypothetical protein -
LOE27_RS19720 (LOE27_19705) 155598..155864 - 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE27_RS19725 (LOE27_19710) 155861..156112 - 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE27_RS19730 (LOE27_19715) 156744..157655 - 912 Protein_149 IS3 family transposase -
LOE27_RS19735 (LOE27_19720) 157656..158600 - 945 Protein_150 transposase -
LOE27_RS19740 (LOE27_19725) 158766..159257 + 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE27_RS19745 (LOE27_19730) 159499..159855 + 357 WP_224556951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fcl / gmd 1..277102 277102
- flank IS/Tn - - 156744..157571 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224485 WP_224556955.1 NZ_CP086809:c155864-155598 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224485 NZ_CP120335:3521917-3522135 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224485 WP_224556953.1 NZ_CP086809:c156112-155861 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224485 NZ_CP120335:3521515-3521889 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References