Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 14117..14631 Replicon plasmid P1
Accession NZ_CP086799
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-47

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE37_RS19355 Protein ID WP_224557656.1
Coordinates 14365..14631 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A074T9H5
Locus tag LOE37_RS19350 Protein ID WP_036743750.1
Coordinates 14117..14368 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE37_RS19325 (LOE37_19320) 9639..10550 - 912 WP_229940889.1 branched-chain amino acid ABC transporter permease -
LOE37_RS19330 (LOE37_19325) 10569..11750 - 1182 WP_229940888.1 ABC transporter substrate-binding protein -
LOE37_RS19335 (LOE37_19330) 12239..12640 + 402 WP_229941941.1 AraC family transcriptional regulator ligand-binding domain-containing protein -
LOE37_RS19340 (LOE37_19335) 12631..13152 + 522 WP_229941939.1 helix-turn-helix domain-containing protein -
LOE37_RS19345 (LOE37_19340) 13324..14010 + 687 WP_224557655.1 helix-turn-helix transcriptional regulator -
LOE37_RS19350 (LOE37_19345) 14117..14368 + 252 WP_036743750.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE37_RS19355 (LOE37_19350) 14365..14631 + 267 WP_224557656.1 Txe/YoeB family addiction module toxin Toxin
LOE37_RS19360 (LOE37_19355) 14874..15917 - 1044 WP_224557657.1 IS5 family transposase -
LOE37_RS19365 (LOE37_19360) 15951..16142 - 192 WP_224557658.1 hypothetical protein -
LOE37_RS19370 (LOE37_19365) 16785..17369 - 585 WP_229941940.1 ParA family protein -
LOE37_RS19375 (LOE37_19370) 17567..18601 - 1035 WP_151654626.1 replication initiator protein A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37716 37716
- flank IS/Tn - - 14874..15917 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10381.70 Da        Isoelectric Point: 8.9104

>T224478 WP_224557656.1 NZ_CP086799:14365-14631 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVSTNDKVRDRINELIKQCKRTPFKGSGLPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224478 NZ_CP120334:28885-29367 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.38 Da        Isoelectric Point: 5.6864

>AT224478 WP_036743750.1 NZ_CP086799:14117-14368 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLDTWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEERE
LTE

Download         Length: 252 bp

>AT224478 NZ_CP120334:28610-28894 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A074T9H5

References