Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 9974..10488 Replicon plasmid P1
Accession NZ_CP086791
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-67

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE38_RS19305 Protein ID WP_224557656.1
Coordinates 9974..10240 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A074T9H5
Locus tag LOE38_RS19310 Protein ID WP_036743750.1
Coordinates 10237..10488 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE38_RS19285 (LOE38_19275) 6003..7037 + 1035 WP_151654626.1 replication initiator protein A -
LOE38_RS19290 (LOE38_19280) 7152..7820 + 669 WP_151654624.1 ParA family protein -
LOE38_RS19295 (LOE38_19285) 8463..8654 + 192 WP_224557658.1 hypothetical protein -
LOE38_RS19300 (LOE38_19290) 8688..9731 + 1044 WP_224557657.1 IS5 family transposase -
LOE38_RS19305 (LOE38_19295) 9974..10240 - 267 WP_224557656.1 Txe/YoeB family addiction module toxin Toxin
LOE38_RS19310 (LOE38_19300) 10237..10488 - 252 WP_036743750.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE38_RS19315 (LOE38_19305) 10595..11281 - 687 WP_224557655.1 helix-turn-helix transcriptional regulator -
LOE38_RS19320 (LOE38_19310) 11453..12517 - 1065 WP_224557654.1 AraC family transcriptional regulator -
LOE38_RS19325 (LOE38_19315) 12855..14036 + 1182 WP_229940888.1 ABC transporter substrate-binding protein -
LOE38_RS19330 (LOE38_19320) 14055..14966 + 912 WP_229940889.1 branched-chain amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37725 37725
- flank IS/Tn - - 8688..9731 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10381.70 Da        Isoelectric Point: 8.9104

>T224470 WP_224557656.1 NZ_CP086791:c10240-9974 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVSTNDKVRDRINELIKQCKRTPFKGSGLPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224470 NZ_CP120333:2101799-2101902 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.38 Da        Isoelectric Point: 5.6864

>AT224470 WP_036743750.1 NZ_CP086791:c10488-10237 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLDTWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEERE
LTE

Download         Length: 252 bp

>AT224470 NZ_CP120333:c2101904-2101759 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A074T9H5

References