Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 34689..35203 Replicon plasmid P10
Accession NZ_CP086774
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-74

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE41_RS24785 Protein ID WP_224557656.1
Coordinates 34937..35203 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A074T9H5
Locus tag LOE41_RS24780 Protein ID WP_036743750.1
Coordinates 34689..34940 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE41_RS24760 (LOE41_24745) 30211..31068 - 858 WP_224557653.1 branched-chain amino acid ABC transporter permease -
LOE41_RS24765 (LOE41_24750) 31141..32322 - 1182 WP_229940888.1 ABC transporter substrate-binding protein -
LOE41_RS24770 (LOE41_24755) 32660..33724 + 1065 WP_224557654.1 AraC family transcriptional regulator -
LOE41_RS24775 (LOE41_24760) 33896..34582 + 687 WP_224557655.1 helix-turn-helix transcriptional regulator -
LOE41_RS24780 (LOE41_24765) 34689..34940 + 252 WP_036743750.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE41_RS24785 (LOE41_24770) 34937..35203 + 267 WP_224557656.1 Txe/YoeB family addiction module toxin Toxin
LOE41_RS24790 (LOE41_24775) 35446..36489 - 1044 WP_224557657.1 IS5 family transposase -
LOE41_RS24795 (LOE41_24780) 36523..36714 - 192 WP_224557658.1 hypothetical protein -
LOE41_RS24800 (LOE41_24785) 37357..38025 - 669 WP_151654624.1 ParA family protein -
LOE41_RS24805 (LOE41_24790) 38140..39174 - 1035 WP_151654626.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..41460 41460
- flank IS/Tn - - 35446..36489 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10381.70 Da        Isoelectric Point: 8.9104

>T224456 WP_224557656.1 NZ_CP086774:34937-35203 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVSTNDKVRDRINELIKQCKRTPFKGSGLPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224456 NZ_CP120331:2101795-2101898 [Salmonella enterica subsp. enterica serovar Muenchen]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.38 Da        Isoelectric Point: 5.6864

>AT224456 WP_036743750.1 NZ_CP086774:34689-34940 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLDTWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEERE
LTE

Download         Length: 252 bp

>AT224456 NZ_CP120331:c2101900-2101755 [Salmonella enterica subsp. enterica serovar Muenchen]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A074T9H5

References