Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 35976..36490 Replicon plasmid P1
Accession NZ_CP086765
Organism Pseudosulfitobacter pseudonitzschiae strain TT37-74

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LOE41_RS19405 Protein ID WP_224556955.1
Coordinates 35976..36242 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LOE41_RS19410 Protein ID WP_224556953.1
Coordinates 36239..36490 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOE41_RS19390 (LOE41_19385) 33204..34085 + 882 WP_224556958.1 zinc-binding dehydrogenase -
LOE41_RS19395 (LOE41_19390) 34303..35006 - 704 Protein_34 IS6 family transposase -
LOE41_RS19400 (LOE41_19395) 35097..35915 + 819 WP_229940646.1 hypothetical protein -
LOE41_RS19405 (LOE41_19400) 35976..36242 - 267 WP_224556955.1 Txe/YoeB family addiction module toxin Toxin
LOE41_RS19410 (LOE41_19405) 36239..36490 - 252 WP_224556953.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LOE41_RS19415 (LOE41_19410) 37122..38033 - 912 Protein_38 IS3 family transposase -
LOE41_RS19420 (LOE41_19415) 38034..38978 - 945 Protein_39 transposase -
LOE41_RS19425 (LOE41_19420) 39144..39635 + 492 WP_224557005.1 3-keto-5-aminohexanoate cleavage protein -
LOE41_RS19430 (LOE41_19425) 39877..40233 + 357 WP_224556951.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..168031 168031
- flank IS/Tn - - 37122..37949 827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.78 Da        Isoelectric Point: 9.5014

>T224452 WP_224556955.1 NZ_CP086765:c36242-35976 [Pseudosulfitobacter pseudonitzschiae]
VKLVFSDQAWEDYQYWVNTNDKVRDRINELIKQCRRTPFKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVSGTGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T224452 NZ_CP120330:c50639-50358 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.43 Da        Isoelectric Point: 6.4652

>AT224452 WP_224556953.1 NZ_CP086765:c36490-36239 [Pseudosulfitobacter pseudonitzschiae]
MDVMTYSDARAQLKGVMDRAIHDKQEVVVTRKKGESVVVVSLETWNAVNETLHLLSTPKNASRLRASIAQLDAGTGEVRE
LTE

Download         Length: 252 bp

>AT224452 NZ_CP120330:c50880-50629 [Salmonella enterica subsp. enterica serovar Muenchen]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References