Detailed information of TA system TA224412

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1822717..1822940
• Replicon: chromosome
• Accession: NZ_CP086726
• Organism: Enterococcus faecalis strain E533

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM507_RS08740
• Protein ID: WP_075551663.1
• Coordinates: 1822717..1822818 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1822763..1822940 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM507_RS08720	1818061..1818957	-	897	WP_002354953.1	YitT family protein	-
LM507_RS08725	1819147..1819653	-	507	WP_010820308.1	cysteine hydrolase family protein	-
LM507_RS08730	1819824..1822094	+	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LM507_RS08735	1822284..1822385	+	102	WP_075551663.1	putative holin-like toxin	-
LM507_RS08740	1822717..1822818	+	102	WP_075551663.1	putative holin-like toxin	Toxin
-	1822763..1822940	-	178	-	-	Antitoxin
LM507_RS08745	1823003..1823455	-	453	WP_002354958.1	YueI family protein	-
LM507_RS08750	1823640..1824587	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LM507_RS08755	1824584..1825549	+	966	WP_002367415.1	iron chelate uptake ABC transporter family permease subunit	-
LM507_RS08760	1825546..1826301	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LM507_RS08765	1826340..1827293	+	954	WP_010820307.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T224412 WP_075551663.1 NZ_CP086726:1822717-1822818 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T224412 NZ_CP120323:11611-11916 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Nucleotide

• Length: 178 bp

>AT224412 NZ_CP086726:c1822940-1822763 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin