Detailed information of TA system TA224405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1749314..1749576
• Replicon: chromosome
• Accession: NZ_CP086726
• Organism: Enterococcus faecalis strain E533

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LM507_RS08375
• Protein ID: WP_002392696.1
• Coordinates: 1749314..1749457 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1749431..1749576 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM507_RS08355	1744655..1746787	+	2133	WP_010820331.1	DNA mismatch repair endonuclease MutL	-
LM507_RS08360	1746812..1747366	+	555	WP_010820330.1	Maf family protein	-
LM507_RS08365	1747499..1747936	+	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LM507_RS08370	1748111..1749082	+	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LM507_RS08375	1749314..1749457	+	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	1749431..1749576	-	146	-	-	Antitoxin
LM507_RS08380	1749826..1750476	-	651	WP_002367457.1	beta-phosphoglucomutase	-
LM507_RS08385	1750491..1753235	-	2745	WP_025190014.1	glycosyl hydrolase family 65 protein	-
LM507_RS08390	1753497..1754210	+	714	WP_010820328.1	trehalose operon repressor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T224405 WP_002392696.1 NZ_CP086726:1749314-1749457 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T224405 NZ_CP120322:2274637-2274792 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 146 bp

>AT224405 NZ_CP086726:c1749576-1749431 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin