Detailed information of TA system TA224394

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1044288..1044516
• Replicon: chromosome
• Accession: NZ_CP086726
• Organism: Enterococcus faecalis strain E533

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LM507_RS04965
• Protein ID: WP_219843903.1
• Coordinates: 1044406..1044516 (-)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1044288..1044423 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM507_RS04945	1039777..1040865	-	1089	WP_002355572.1	diacylglycerol kinase	-
LM507_RS04950	1040884..1042314	-	1431	WP_002358703.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB	-
LM507_RS04955	1042314..1043783	-	1470	WP_010819760.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA	-
LM507_RS04960	1043783..1044088	-	306	WP_010819759.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
-	1044288..1044423	+	136	-	-	Antitoxin
LM507_RS04965	1044406..1044516	-	111	WP_219843903.1	putative holin-like toxin	Toxin
LM507_RS04970	1044670..1046700	-	2031	WP_081115754.1	NAD-dependent DNA ligase LigA	-
LM507_RS04975	1046826..1049084	-	2259	WP_010708284.1	DNA helicase PcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 3805.59 Da
• Isoelectric Point: 5.9482

>T224394 WP_219843903.1 NZ_CP086726:c1044516-1044406 [Enterococcus faecalis]
MSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Nucleotide

• Length: 111 bp

>T224394 NZ_CP120319:17800-18105 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Nucleotide

• Length: 136 bp

>AT224394 NZ_CP086726:1044288-1044423 [Enterococcus faecalis]
TGAAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGG
TTTTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTT

Structures

Antitoxin