Detailed information of TA system TA022439

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 16680..16938
• Replicon: chromosome
• Accession: NC_009801
• Organism: Escherichia coli E24377A

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: ECE24377A_RS01720
• Protein ID: WP_000809168.1
• Coordinates: 16680..16832 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	16881..16938 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECE24377A_RS01700	11921..12634	-	714	WP_001102383.1	acidic protein MsyB	-
ECE24377A_RS01705	12660..13064	-	405	WP_000843559.1	DUF2541 family protein	-
ECE24377A_RS01710	13441..15357	+	1917	WP_000516135.1	molecular chaperone DnaK	-
ECE24377A_RS01715	15446..16576	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
ECE24377A_RS01720	16680..16832	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	16881..16938	+	58	-	-	Antitoxin
ECE24377A_RS01725	17418..18584	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
ECE24377A_RS01730	18650..19549	+	900	WP_001300855.1	transcriptional activator NhaR	-
ECE24377A_RS01735	19588..20547	-	960	WP_000871667.1	hypothetical protein	-
ECE24377A_RS01740	20560..21891	-	1332	Protein_19	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T22439 WP_000809168.1 NC_009801:c16832-16680 [Escherichia coli O139:H28 str. E24377A]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T22439 NC_009801:c16832-16680 [Escherichia coli O139:H28 str. E24377A]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT22439 NC_009801:16881-16938 [Escherichia coli O139:H28 str. E24377A]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin