Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 16680..16938 Replicon chromosome
Accession NC_009801
Organism Escherichia coli E24377A

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag ECE24377A_RS01720 Protein ID WP_000809168.1
Coordinates 16680..16832 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 16881..16938 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECE24377A_RS01700 11921..12634 - 714 WP_001102383.1 acidic protein MsyB -
ECE24377A_RS01705 12660..13064 - 405 WP_000843559.1 DUF2541 family protein -
ECE24377A_RS01710 13441..15357 + 1917 WP_000516135.1 molecular chaperone DnaK -
ECE24377A_RS01715 15446..16576 + 1131 WP_001118464.1 molecular chaperone DnaJ -
ECE24377A_RS01720 16680..16832 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 16881..16938 + 58 - - Antitoxin
ECE24377A_RS01725 17418..18584 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
ECE24377A_RS01730 18650..19549 + 900 WP_001300855.1 transcriptional activator NhaR -
ECE24377A_RS01735 19588..20547 - 960 WP_000871667.1 hypothetical protein -
ECE24377A_RS01740 20560..21891 - 1332 Protein_19 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T22439 WP_000809168.1 NC_009801:c16832-16680 [Escherichia coli O139:H28 str. E24377A]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T22439 NC_009801:c16832-16680 [Escherichia coli O139:H28 str. E24377A]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT22439 NC_009801:16881-16938 [Escherichia coli O139:H28 str. E24377A]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References