22431

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2135065..2135567 Replicon chromosome
Accession NC_009800
Organism Escherichia coli HS

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7I6H4L3
Locus tag ECHS_RS10710 Protein ID WP_000767831.1
Coordinates 2135065..2135319 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag ECHS_RS10715 Protein ID WP_001259255.1
Coordinates 2135316..2135567 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECHS_RS10685 (EcHS_A2150) 2130080..2130307 - 228 WP_000985273.1 sulfurtransferase TusA family protein -
ECHS_RS10690 (EcHS_A2151) 2130321..2131379 - 1059 WP_000492321.1 transport protein YeeE -
ECHS_RS10695 (EcHS_A2152) 2131558..2132916 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
ECHS_RS25535 2132906..2132968 - 63 WP_010723108.1 membrane protein YoeI -
ECHS_RS10700 (EcHS_A2153) 2133183..2134112 - 930 WP_000803366.1 LysR family transcriptional regulator -
ECHS_RS10705 (EcHS_A2154) 2134158..2134982 - 825 WP_000754737.1 SDR family oxidoreductase -
ECHS_RS10710 (EcHS_A2155) 2135065..2135319 - 255 WP_000767831.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
ECHS_RS10715 (EcHS_A2156) 2135316..2135567 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
ECHS_RS23850 (EcHS_A2157) 2135851..2135901 + 51 WP_001364200.1 his operon leader peptide -
ECHS_RS10720 (EcHS_A2158) 2136047..2136946 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
ECHS_RS10725 (EcHS_A2159) 2136952..2138256 + 1305 WP_001565639.1 histidinol dehydrogenase -
ECHS_RS10730 (EcHS_A2160) 2138253..2139323 + 1071 WP_000108945.1 histidinol-phosphate transaminase -
ECHS_RS10735 (EcHS_A2161) 2139323..2140390 + 1068 WP_000080094.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10231.67 Da        Isoelectric Point: 8.8202

>T22431 WP_000767831.1 NC_009800:c2135319-2135065 [Escherichia coli HS]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTYDSLLIAAC
RYHY

Download         Length: 255 bp

>T22431 NC_009800:c2135319-2135065 [Escherichia coli HS]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT22431 WP_001259255.1 NC_009800:c2135567-2135316 [Escherichia coli HS]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT22431 NC_009800:c2135567-2135316 [Escherichia coli HS]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I6H4L3

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References