Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 274882..275401 Replicon chromosome
Accession NZ_CP086659
Organism Staphylococcus capitis strain XZ03

Toxin (Protein)


Gene name yoeB Uniprot ID A0A507SVT5
Locus tag LN243_RS01185 Protein ID WP_002436254.1
Coordinates 274882..275151 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J4EAU6
Locus tag LN243_RS01190 Protein ID WP_002436168.1
Coordinates 275144..275401 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN243_RS01165 270055..271746 + 1692 WP_229346802.1 YSIRK-type signal peptide-containing protein -
LN243_RS01170 271860..272618 + 759 WP_030059220.1 alpha/beta hydrolase family protein -
LN243_RS01175 273161..274309 + 1149 WP_172969460.1 CapA family protein -
LN243_RS01180 274373..274738 - 366 WP_002436243.1 DUF4870 domain-containing protein -
LN243_RS01185 274882..275151 - 270 WP_002436254.1 Txe/YoeB family addiction module toxin Toxin
LN243_RS01190 275144..275401 - 258 WP_002436168.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LN243_RS01195 275586..276443 + 858 WP_002454139.1 ABC transporter substrate-binding protein -
LN243_RS01200 276553..278193 - 1641 WP_030059216.1 alpha-keto acid decarboxylase family protein -
LN243_RS01205 278366..278821 + 456 WP_002436214.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10524.00 Da        Isoelectric Point: 9.7885

>T224284 WP_002436254.1 NZ_CP086659:c275151-274882 [Staphylococcus capitis]
MSKFSVTFTAQAFKDYQYWQQHNQNYFKKVNALLKSIARDGCVDGIGKPEALKGNYEGYFSRRVSIEHRLIYKIKDDSIF
VVSCRFHYQ

Download         Length: 270 bp

>T224284 NZ_CP119980:c4185581-4185213 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTTGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9737.79 Da        Isoelectric Point: 4.1359

>AT224284 WP_002436168.1 NZ_CP086659:c275401-275144 [Staphylococcus capitis]
MPSVNYSNARQNFKELITKVNEDSVAYTITTKENENAVILAEKDYNAMLETMYLQSNLANVSHLNQSIMELNHNQTITIE
IDDNE

Download         Length: 258 bp

>AT224284 NZ_CP119980:c4185799-4185578 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SVT5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4EAU6

References